The isolation of biologically active compounds from medicinal plants, determination of their chemical structures, and evaluation of their pharmacological and toxicological properties constitute one of the key areas of modern pharmaceutical science and experimental medicine. The present study is devoted to the experimental evaluation of the hemostatic and coagulant activity of Lagochilus inebrians (introduced species) extract. The results demonstrate that the hemostatic effect of Lagochilus inebrians extract is associated with the influence of lagoxylin and its derivatives on the intrinsic mechanisms of the blood coagulation system. The obtained data substantiate the prospects for further pharmacological and clinical investigations of this plant extract as an effective natural-source-based hemostatic agent.

Lagochilus inebrians, lagoxylin, medicinal plants, hemostatic activity, coagulant effect, hepatic parenchymal bleeding, rat model, biologically active compounds.

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