This study investigates the intricate relationship between information technology (IT) integration, user perception, and performance in selected public hospitals in Kenya. With the increasing adoption of IT in healthcare settings, understanding how IT integration influences hospital performance through user perception is crucial for optimizing healthcare delivery. Through a mixed-methods approach, including surveys and interviews, data were collected from healthcare professionals and administrators in public hospitals. Statistical analyses and thematic coding were used to explore the mediating role of user perception in the relationship between IT integration and hospital performance. Preliminary findings suggest that user perception plays a significant mediating role, influencing the extent to which IT integration impacts hospital performance. Positive user perceptions enhance the effectiveness of IT integration, leading to improved performance outcomes such as patient care quality and operational efficiency. Conversely, negative perceptions may hinder the realization of IT benefits. These findings underscore the importance of considering user perceptions when designing and implementing IT systems in healthcare settings.