Chromatin remodeling plays a crucial role in regulating gene expression during cellular differentiation processes such as adipogenesis and myogenesis. Adipocytes and myocytes undergo distinct differentiation pathways governed by specific transcriptional programs, where chromatin structure undergoes dynamic changes to facilitate lineage-specific gene expression. This comparative analysis explores genome-wide chromatin remodeling events in adipogenesis and myogenesis, focusing on histone modifications, nucleosome positioning, and higher-order chromatin organization. Integrating data from high-throughput sequencing technologies, we identify key regulatory regions and chromatin domains that undergo significant structural alterations during these differentiation processes. By comparing and contrasting these epigenetic landscapes, we elucidate common and distinct mechanisms underlying adipogenic and myogenic differentiation, offering insights into the regulatory networks that orchestrate tissue-specific gene expression. Understanding these chromatin dynamics provides a foundation for unraveling the molecular basis of adipose and muscle tissue development, with implications for therapeutic strategies targeting metabolic and musculoskeletal disorders.

Chromatin remodeling, Adipogenesis, Myogenesis

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