This study delves into the intricate world of Indonesian fermented foods, exploring the multifaceted nature of bacteriocins produced by Lactobacillus plantarum isolates. Through meticulous characterization, we unravel the diversity and potency of these culinary guardians, shedding light on their potential applications. Employing advanced molecular techniques, we identify and elucidate the plantaricin-encoding genes responsible for the unique antimicrobial properties exhibited by these isolates. Our findings not only contribute to the understanding of indigenous microbial communities in traditional foods but also offer insights into harnessing these natural agents for enhancing food safety and preservation.

"Combination Therapy Regulation: Attenuating Cardiac Metabolic Remodeling in Heart Failure" examines the potential of combination therapy in mitigating cardiac metabolic remodeling, a key contributor to heart failure (HF) progression. This paper explores the rationale, mechanistic insights, and clinical implications of combination therapy as a novel approach to modulate cardiac metabolism and preserve myocardial function in HF. By concurrently targeting multiple metabolic pathways implicated in HF pathophysiology, combination therapy holds promise for optimizing myocardial energetics, attenuating adverse remodeling, and improving clinical outcomes in patients with HF.