"Combination Therapy Regulation: Attenuating Cardiac Metabolic Remodeling in Heart Failure" examines the potential of combination therapy in mitigating cardiac metabolic remodeling, a key contributor to heart failure (HF) progression. This paper explores the rationale, mechanistic insights, and clinical implications of combination therapy as a novel approach to modulate cardiac metabolism and preserve myocardial function in HF. By concurrently targeting multiple metabolic pathways implicated in HF pathophysiology, combination therapy holds promise for optimizing myocardial energetics, attenuating adverse remodeling, and improving clinical outcomes in patients with HF.

Combination therapy, cardiac metabolism, metabolic remodeling

Hu X, Tang ZH, Ma SY, Yu YS, Chen XH, Zang GQ. Tripartite motif-containing protein 7 regulates hepatocellular carcinoma cell proliferation via the DUSP6/p38 pathway. Biochem Biophys Res Commun. 2019; 511: 889-895.

Yancy CW, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American college of cardiology/American heart association task force on clinical practice guidelines and the heart failure society of America. J Am Coll Cardiol. 2017; 70: 776-803.

Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013; 113: 709-724.

van Bilsen M, Smeets PJ, Gilde AJ, van der Vusse GJ. Metabolic remodelling of the failing heart: the cardiac burn-out syndrome? Cardiovasc Res. 2004; 61: 218-226.

Bertero E, Maack C. Metabolic remodelling in heart failure. Nat Rev Cardiol. 2018; 15: 457-470.

Garcia-Ropero A, Santos-Gallego CG, Zafar MU, Badimon JJ. Metabolism of the failing heart and the impact of SGLT2 inhibitors. Expert Opin Drug Metab Toxicol. 2019; 15: 275-285.

Zhou B, Tian R. Mitochondrial dysfunction in pathophysiology of heart failure. J Clin Invest. 2018; 128: 3716-3726.

Riehle C, Abel ED. Insulin signaling and heart failure. Circ Res. 2016; 118: 1151-1169.

Wei HM, Wu HJ, Yu W, Yan X, Zhang XY. Shenfu decoction as adjuvant therapy for improving quality of life and hepatic dysfunction in patients with symptomatic chronic heart failure. J Ethnopharmacol. 2015; 169: 347-355.

Chen YF, Yu RY, Jiang L, et al. A comprehensive and rapid quality evaluation method of traditional chinese medicine decoction by integrating UPLC-QTOF- MS and UFLC-QQQ-MS and its application. Molecules. 2019; 24: 374.

Song YL, Zhang N, Shi SP, et al. Large-scale qualitative and quantitative characterization of components in Shenfu injection by integrating hydrophilic interaction chromatography, reversed phase liquid chromatography, and tandem mass spectrometry. J Chromatogr A. 2015; 1407: 106-118.

Luo J, Min S, Wei K, Cao J. Ion channel mechanism and ingredient bases of Shenfu Decoction's cardiac electrophysiological effects. J Ethnopharmacol. 2008; 117: 439-445.