Skeletal muscle development and maintenance are critical for overall health and functionality. Recent research has highlighted the pivotal roles of nutrients and microRNAs (miRNAs) in regulating the complex signaling networks that govern these processes. Nutrients act as essential building blocks and signaling molecules, influencing gene expression and cellular metabolism. Concurrently, miRNAs have emerged as crucial regulators of gene expression, modulating the activity of various signaling pathways involved in muscle growth, differentiation, and repair.

This review delves into the intricate interplay between nutrients and miRNAs in skeletal muscle biology. We explore how specific nutrients, such as amino acids, fatty acids, and vitamins, impact miRNA expression and function. Additionally, we discuss the mechanisms by which miRNAs mediate nutrient-responsive signaling pathways, influencing key aspects of muscle physiology, including myogenesis, hypertrophy, and response to stress and injury.

Understanding the synergistic effects of nutrients and miRNAs provides novel insights into the molecular basis of muscle development and disease. This knowledge holds significant potential for the development of targeted nutritional and therapeutic strategies aimed at preventing and treating muscle-related disorders, such as sarcopenia, muscular dystrophies, and metabolic diseases. By integrating nutrient and miRNA research, we can advance our understanding of muscle health and pave the way for innovative interventions in skeletal muscle pathophysiology.

Skeletal muscle development, Muscle signaling pathways, Nutrient regulation

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