Chronic recurrent aphthous stomatitis is an inflammatory disease of the oral mucosa, characterized by the appearance of aphthous lesions, a long course with periodic relapses and is often accompanied by diseases of the gastrointestinal tract. Chronic cholecystitis is an inflammatory disease of the gallbladder wall. It develops due to the formation of stones in the gallbladder, which leads to stagnation of bile. Periodically arising and passing inflammations lead to changes in the wall of the gallbladder with the development of chronic calculous cholecystitis in it. Along with the general clinical signs of chronic calculous cholecystitis, changes in the oral mucosa develop.

In most cases of chronic calculous cholecystitis on the oral mucosa, patients feel discomfort caused by swelling, the appearance of aphthae, erosions, ulcers and other changes. In chronic cholecystitis, we observed patients with chronic recurrent aphthous stomatitis, which occurred equally often in both women and men. Diagnosis of chronic recurrent aphthous stomatitis is often limited only to objective data on the clinical manifestations of the disease on the oral mucosa. Biopsy of aphthae on the oral mucosa is usually not performed. The prevalence of chronic recurrent aphthous stomatitis in chronic cholecystitis is very variable, ranging from 5 to 60% and depends on the population studied, environmental factors and diagnostic criteria. A number of authors believe that the results of treatment of chronic recurrent aphthous stomatitis against the background of digestive diseases are not always satisfactory due to frequent relapses.

The purpose of the study: justification of pathomorphological studies for the diagnosis of chronic recurrent aphthous stomatitis in chronic calculous cholecystitis.

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