The human skin is not merely a physical barrier but a complex ecosystem hosting a diverse community of microorganisms known as the microbiome. Disruption of this microbial balance, or dysbiosis, is increasingly recognized as a precursor to various dermatological conditions, including atopic dermatitis and acne vulgaris. This article presents a study conducted at the Department of Dermatology and Venereology of Andijan State Medical Institute. Using the IMRAD framework, the research evaluates the efficacy of a preventive skincare regimen focused on microbiome support compared to traditional hygiene practices. The study involved sixty participants with early signs of skin barrier compromise. One group utilized aggressive antibacterial cleansers, while the other used pH-balanced prebiotic formulations. The results indicate that preserving the acid mantle and supporting commensal flora significantly reduces transepidermal water loss and inflammatory markers. The study concludes that shifting the paradigm from "sterilization" to "microbiome stewardship" offers a potent strategy for the primary prevention of skin diseases.

skin microbiome, dysbiosis, prevention, prebiotics, skin barrier function, dermatology, pH balance.

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