Articles
| Open Access |
https://doi.org/10.55640/
DEFORMATIVE OSTEOARTHRITIS
Shermatov Kholbek,Bakhromov Asliddin , Scientific advisor: Termez University of Economics and Service Assistant of the Department of Medical Clinical Sciences ,Termez University of Economics and Service Faculty of Medicine, Department of Therapeutic Work 3rd year studentAbstract
The pathogenesis of osteoarthritis of the knee (OAH) is interpreted in modern rheumatology as a complex cascade process resulting from the activation of pro-inflammatory mediators (IL-1β, TNF-α) and matrix metalloproteinases (MMP-13). This study analyzes the limitations of traditional drug therapy in restoring joint homeostasis and the therapeutic efficacy of regenerative medicine methods, in particular autologous plasma (PRP) and stromal vascular fraction (SVF) at the molecular level. The results obtained provide scientific justification for the possibility of modifying the pathological process at early stages and inhibiting chondrocyte apoptosis.
Keywords
Osteoarthritis, chondrosenescence, MMP-13, Kellgren-Lawrence classification, PRP therapy, SVF technology, chondromalacia, subchondral remodeling.
References
Hunter D.J., Bierma-Zeinstra S. "Osteoarthritis". The Lancet, 2019; 393: 1745–1759.
OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis and Cartilage, 2024.
Bannuru R.R., et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage, 2019; 27(11): 1578-1589.
G.L. Gumirova, et al. "Modern aspects of complex treatment of osteoarthritis". Journal of Rheumatology, 2023.
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