Today, the number of patients with diabetes mellitus (DM) is increasing year by year in the world. In order to maintain blood glucose levels at a normal level, patients with diabetes mellitus need to set daily norms for themselves, such as diet, insulin, and other means of lowering blood sugar, and strictly adhere to them. For this, patients need to regularly check their blood glucose levels at home or in medical institutions. Currently, glucose measurement is widely used in clinical diagnostic laboratories. When determining the level of glucose in the human body using a standard glucometer, the patient experiences painful sensations. In addition, with each new measurement, the patient can infect himself with some disease or infection that enters the body with blood (for example, hepatitis C, AIDS). Also, daily pricking of the patient's finger with a needle causes various inconveniences for the patient. Therefore, the diagnosis of diabetes mellitus is becoming more and more difficult. In such a situation, the use of non-invasive methods of measuring glucose levels is effective. This article studies the issue of mathematical modeling of glucose level monitoring in diabetes mellitus based on electrical resistance (ER) values ​​obtained from bioactive points (BAPs) informative for the BD of the human body.

bioactive active points, invasive, non-invasive, glucometer.

Ahn W, Kim J-T. Blood Glucose Measurement Principles of Non-invasive Blood Glucose Meter: Focused on the Detection Methods of Blood Glucose. Int J Biomed Eng Technol. 2012; 33(3):114-127. doi: 10.9718/jber.2012.33.3.114

Бабенко А.Ю., Кононова Ю.А., Циберкин А.И., Ходзицкий М.К., Гринева Е.Н. Динамика развития методов контроля гликемии от инвазивных к неинвазивным. Актуальные перспективы //Сахарный диабет. 2016. –Т.19, №5. doi: 10.14341/ DM7760. С.397-405.

Эльбаева А.Д. Неинвазивные методы диагностики концентрации глюкозы и холестерина в крови // Международный журнал прикладных и фундаментальных исследований. 2016, № 6-2. – С. 301-305.

H.M. Heise, R. Marbach, G. Janatsch, J.D. Kruse-Jarres, Determination of Glucose in Whole Blood Attenuated Total Reflection Infrared Spectroscopy,‖ Anal. Chem. 1989: 61, 2009-2015.

Siddiqui, S.A.; Zhang, Y.; Lloret, J.; Song, H.; Obradovic, Z. Pain-Free Blood Glucose Monitoring Using Wearable Sensors: Recent Advancements and Future Prospects. IEEE Rev. Biomed. Eng. 2018, 11, 21–35. [CrossRef]

Bazaev, N.A.; Masloboev, I.P.; Selishchev, S.V. Optical methods for noninvasive blood glucose monitoring. Med. Tekh. 2011, 29–33. [CrossRef]

Rukkumani V, Radhika V, Sivasankari S, Veera Vanitha. Non Invasive Determination of Blood Group Typing Blood Glucose and Haemoglobin Analysis Turkish Journal of Computer and Mathematics Education Vol.12 No. 7 (2021), 1506-1509.

https://www.labmedica.com/technology/articles/294795440/revolutionary-non-invasive-technique-measures-glucose-levels-without-drawing-blood.html

S. Mohanram and A. Shirly Edward. Measurement of Blood Glucose using Non-Invasive Methods – A Review. 2021 J. Phys.: Conf. Ser. 1964 062022

Liu Tang, Shwu Jen Chang, Ching-Jung Chen, and Jen-Tsai Liu. Non-Invasive Blood Glucose Monitoring Technology: A Review Sensors 2020, 20(23), 6925; https://doi.org/10.3390/s20236925

Laha, S.; Rajput, A.; Laha, S.S.; Jadhav, R. A Concise and Systematic Review on Non-Invasive Glucose Monitoring for Potential Diabetes Management. Biosensors. 2022, 12, 965. https://doi.org/10.3390/bios12110965

Портнов, Ф.Г. Электропунктурная рефлексотерапия. Рига: Зинатне. 1987. 352 с.

Huodo M.D. Ruodoraky treatment and objective approach to acupuncture. Amer.Jur. Acupuncture. – 1984. - Vol.12, №3. - pр. 229-238.

Gafarov Gadir and Rustamova Durdane. Biologically Active Points and Application Possibilities in Medicine. International Journal of Academic Health and Medical Research (IJAHMR) ISSN: 2643-9824. Vol. 6 Issue 11, November - 2022, pp.1-4.

A.Guliev, G.Jo`raev, U.Turapov. The use of indicators of electrical resistance of bioactive points located in the meridians of the human body in the diagnosis and treatment of diabetes mellitus. International Scientific Journal "Science and Innovation". Series A. Volume 1 Issue 8. UIF-2022: 8.2 | ISSN: 2181-3337. pp.410-417.

Гулиев А.А., Жураев Г.У., Турапов У.У. О создание неинвазивного компьютерного биоизмерителя для анализа биофизических показателей биологически активных точек. Ахбороткоммуникациялар: Тармоқлар, технологиялар, Ечимлар. №4(60), Т., 2021. С.20-26

Nakatani Y., Yamashuta K. Riodoraku Akupunkture. Japan. Tokyo. 1977.

Orlov, A.I. Prikladnaia statistika [Applied statistics]. Moscow: Ekzamen Publ., 2004. –656 p.

Бойцов И.В. Электропунктурная диагностика по "Риодораку".

–Витебск, 1996. – 189 с.

Juraev, G. Rakhimberdiev, K. Mathematical Modeling of Credit Scoring System Based on the Monge-Kantorovich Problem. IEEE International IOT, Electronics and Mechatronics Conference, IEMTRONICS 2022, 2022.

Juraev, G., Musurmonova, M. An Algorithm for Solving the Problem of Radial Expansion of a Spherical Cavity Supported by a Thin Spherical Shell in an Elastic-Porous Fluid-Saturated Medium. AIP Conference, 2022, 2432, 030109

Киреев В.И. Численные методы в примерах и задачах. М.: Высшая школа, 2008. -480 с.