Endometriosis is a chronic estrogen-dependent disease characterized by the presence of endometriotic tissue outside the uterine cavity and accompanied by pain, reproductive dysfunction, and a reduced quality of life. Despite its significant prevalence among women of reproductive age, diagnosis remains challenging. Traditionally, laparoscopy with histological confirmation has been considered the "gold standard" for diagnosis verification. However, its invasive nature limits its use as a primary diagnostic method. Therefore, noninvasive methods for detecting endometriosis are particularly relevant. This article presents an analysis of modern instrumental, laboratory, and molecular diagnostic technologies, their information content, limitations, and prospects for their implementation in clinical practice.

endometriosis, non-invasive diagnostics, MRI, transvaginal ultrasound, biomarkers , deep infiltrating endometriosis.

Podzolkova N.M., Fadeev I.E., Mass E.E. et al. Non-invasive diagnosis and non-surgical treatment of endometriosis: review // Gynecology. - 2022. - T. 24, No. 3. - P. 167–173.

Kiselev M. A., Repina N. B. Non-invasive diagnostics of endometriosis: a review of modern biomarkers of peripheral blood and endometrium // Bulletin of the I. P. Pavlov Russian Medical Biological Academy. - 2020. - Vol. 28, No. 3. - P. 371–376.

Rusina E. I., Yarmolinskaya M. I., Ivanova A. O. Modern methods of radiation diagnostics of endometriosis // Journal of obstetrics and women's diseases. - 2020. - Vol. 69, No. 2. - P. 59-72.

Saiddanesh S. F., Chuprynin V. D., Khilkevich E. G., et al. Modern methods of diagnosing common forms of endometriosis // Obstetrics and Gynecology. - 2017. - No. 5. - P. 39-43.

Barinov S. V., Lazareva O. V., Ignatiev Yu. A. et al. Clinical significance of diagnostic methods for genital endometriosis // Obstetrics and Gynecology. - 2018. - No. 12. - P. 75-81.

Yarmolinskaya M. I., Rusina E. I., Khachaturyan A. R., Florova M. S. Clinic and diagnostics of genital endometriosis // Journal of obstetrics and women's diseases. - 2016. - Vol. 65, No. 5. - P. 4–21.

Efimova A. A., Sergienya O. V., Mashchenko I. A., Zazerskaya I. E. Magnetic resonance imaging for non-invasive diagnosis of various forms of endometriosis in women with infertility // Digital Diagnostics . - 2023. - T. 4, No. 1S. — pp. 57–59.