Cardiac Syndrome X (CSX), characterized by typical angina pectoris and positive stress tests despite angiographically normal coronary arteries, remains a diagnostic and therapeutic challenge. This article presents a clinical study conducted at the Department of Faculty Therapy of Andijan State Medical Institute. Using the IMRAD framework, the research investigates the role of the sympathoadrenal system (SAS) in the pathogenesis of CSX. The study involved 60 patients with CSX and a control group of healthy individuals. The functional activity of the SAS was assessed by measuring the daily excretion of catecholamines (adrenaline, noradrenaline) and their precursors. The results demonstrate a state of chronic sympathetic hyperactivity in CSX patients, characterized by elevated catecholamine levels and reduced reserve capacity of the adrenal medulla. The study concludes that autonomic dysregulation is a primary driver of microvascular angina in this population, necessitating targeted sympatholytic therapy.

Cardiac Syndrome X, sympathoadrenal system, microvascular angina, catecholamines, autonomic dysfunction.

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