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| Open Access |
https://doi.org/10.55640/
INTESTINAL MICROBIOTA AND METABOLISM: THEIR BIOCHEMICAL ROLE AS A "NEW ENDOCRINE ORGAN" IN THE HUMAN BODY
Suyunov Farrux Sayfullo o’gli, Pardayeva Azizabonu Ulug'bek qizi, Sulaymonova Zebiniso Ilyos qizi, Adxamov Asror Adxam oʻgʻli , Samarkand State Medical UniversityAbstract
The intestinal microbiota is recognized as an important regulator of metabolism in the human body. The metabolites it produces - short-chain fatty acids (SCFA), signaling molecules that activate incretin secretion, and neuroactive substances - regulate energy metabolism, insulin sensitivity, and central nervous system function. Disruption of the microbiota composition leads to a weakening of the intestinal barrier function, the development of low-grade chronic inflammation, and insulin resistance. This article analyzes the main molecular mechanisms of microbiota's influence on metabolism.
Keywords
intestinal microbiota, SCFA, GLP-1, insulin resistance, obesity, brain-intestinal axis, metabolic syndrome.
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This work is licensed under a Creative Commons Attribution 4.0 International License.