This comprehensive literature review examines the specific features of cognitive impairment and dementia in Parkinson's disease (PD), emphasizing their clinical, neurological, and neurobiological underpinnings. The study highlights the critical importance of early detection of mild cognitive impairment (MCI) and discusses contemporary diagnostic and therapeutic approaches. The review is based on an extensive analysis of publications from international scientific databases, reflecting the current state of research on the role of neuroinflammation and brain structural alterations in the progression of PD-related cognitive decline.

Parkinson’s disease, cognitive impairment, dementia, mild cognitive impairment (MCI), α-synuclein, rivastigmine, neuropsychology, International Parkinson and Movement Disorder Society (IPMDS).

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Abdukodirov, E. I., Raimova, M. M., & Alixonov, S. A. (2023). Transcranial magnetic stimulation therapy in early and late stages of Parkinson's disease. European Journal of Modern Medicine and Practice, 3(1), 31–36.

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Abduqodirov, E. I., Matmurodov, R. J., & Babakulov, Sh. Kh. (2026). Integrated neurocognitive and structural-functional brain changes in Parkinson's disease. Journal of Neurological Sciences of Uzbekistan, 4(1), 12-19.

Abduqodirov, E., Matmurodov, R., Juraev, R., Naimov, O., Muminov, B., Khalimova, K., & Daminova, H. (2023). Glial neurotrophic factor as a differential marker of Parkinson’s disease and vascular parkinsonism. Movement Disorders, 38(289), 120.

Abduqodirov, E., Matmurodov, R., Muminov, B., Daminova, H., Khalimova, K., Naimov, O., & Juraev, R. (2023). Aspects of early detection of Parkinson’s disease in ambulatory settings. Movement Disorders, 38(478), 203.

Amonov, B., Juraev, R. M., Matmurodov, R. J., Khalimova, K., & Abdukodirov, E. I. (2024). Analysis of risk factors affecting the development of vascular parkinsonism by gender. Parkinsonism & Related Disorders, 122.

Amonov, B., Matmurodov, R., Abdukodirov, E., & Khalimova, K. (2021). Sleep disorders as a predictor of Parkinson's disease in Uzbek nationality. Journal of the Neurological Sciences, 429.

Abduqodirov, E. I., Jumanazarova, Sh. R., & Matmurodov, R. J. (2025). Extrapyramidal disorders: clinical-paraclinical parallels. Central Asian Medical Journal, 9(1), 45-50.

Abduqodirov, E. I., & Babakulov, Sh. Kh. (2026). Personalized preventive algorithm for patients with Parkinson’s disease. Uzbek Medical Journal, 6(3).

Isroilovich, A. E., Abdullayeva, M. B., Matmurodov, R. J., Khalimova, K. M., Muminov, B. A., & Naimov, O. Y. (2022). The role and importance of glial neurotrophic factors in early diagnosis of Parkinson disease. Texas Journal of Medical Science, 5, 1–6.

Jumanazarova, Sh. R., Abduqodirov, E. I., Matmurodov, R., Kalanov, A. B., Mamatova, Sh. A., & Inoyatova, S. O. (2025). Clinical and paraclinical aspects of extrapyramidal disorders in patients with cerebrovascular pathology. Movement Disorders, 4(157), S977.

Juraev, R., Abduqodirov, E., Matmurodov, R., & Khalimova, K. (2019). Initial manifestations of Parkinson's disease in Uzbek nationality. Journal of the Neurological Sciences, 405, 302–303.

Khalimova, K. M., Matmurodov, R. J., Turapov, X. R., Muminov, B. A., & Abdukodirov, E. I. (2023). Assessment of indicators of anxiety and depression in patients after COVID-19. World Bulletin of Public Health, 20(1), 140–144.

Matmurodov, R. J., & Abduqodirov, E. I. (2024). Transformation of clinical forms of neuropathy in the post-covid period. Parkinsonism & Related Disorders, 122.

Matmurodov, R., & Abduqodirov, E. (2020). Depression in various forms of parkinsonism and striatal hyperkinesis. Movement Disorders, 35, S335.

Matmurodov, R., & Abduqodirov, E. (2020). Early predictors of Parkinson's disease and prognosis in relatives. Movement Disorders, 35, S207.

Matmurodov, R., Abduqodirov, E., Kalanov, A., Babayeva, F., & Jamalova, S. (2025). Myofascial pain syndromes in parkinsonism. Movement Disorders, 4(S977), 156.

Matmurodov, R., Jumanazarova, S., Abduqodirov, E., & Abdullayeva, M. (2025). Analysis of statistical data on patients with Parkinson’s disease. Movement Disorders, 4(1), S801.