Articles
| Open Access |
https://doi.org/10.55640/
GENE EXPRESSION
Rustamova Ruxshona Omon kizi, Fayzullayeva Farangiz Farxodovna, Nurmòminova Ruhshona Otamurodovna , Samarkand State Medical UniversityAbstract
This article provides a comprehensive overview of gene expression, focusing on its molecular mechanisms, regulation, and biological significance. Gene expression is a multi-level process that determines how genetic information is translated into functional products, such as proteins and RNAs, essential for cellular development, differentiation, and adaptation. The article discusses transcriptional, post-transcriptional, translational, and post-translational regulatory mechanisms, as well as epigenetic modifications that influence gene activity. The relevance of studying gene expression in understanding disease development, including cancer and genetic disorders, is highlighted. Additionally, modern techniques such as RNA sequencing, microarrays, and computational analysis are reviewed for their roles in analyzing gene expression patterns and regulatory networks. The article emphasizes the applications of gene expression knowledge in medicine, biotechnology, and synthetic biology.
Keywords
Gene expression; Transcription; Translation; Regulation; Epigenetics; RNA processing; Protein synthesis; Molecular biology; Cellular function; Disease mechanisms.
References
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2021). Molecular Biology of the Cell (7th ed.). New York: Garland Science.
Lodish, H., Berk, A., Kaiser, C., Krieger, M., Bretscher, A., Ploegh, H., & Matsudaira, P. (2020). Molecular Cell Biology (8th ed.). New York: W. H. Freeman.
Zhang, Y., & Liu, Q. (2021). Regulation of gene expression by transcription factors and epigenetic mechanisms. Frontiers in Genetics, 12, 650345.
Li, X., Liu, Y., & Zhou, H. (2022). Post-transcriptional regulation of gene expression: mechanisms and functions. Genes, 13(3), 482. https://doi.org/10.3390/genes13030482
Wang, Y., & Chen, J. (2020). Advances in RNA sequencing for studying gene expression dynamics. Nature Reviews Genetics, 21(11), 682–700.
Smith, Z. D., & Meissner, A. (2020). Epigenetic regulation of gene expression in development and disease. Nature Reviews Genetics, 21(6), 362–377.
Jones, P. A., & Issa, J. P. (2021). Epigenetic therapies and gene expression regulation in cancer. Nature Reviews Clinical Oncology, 18, 175–193.
Азимова, А. А., Маликов, Д. И., & Шайкулов, Х. Ш. (2021). МОНИТИРОИНГ ЭТИОЛОГИЧЕСКОЙ СТРУКТУРЫ СЕПСИСА ЗА. PEDAGOGICAL SCIENCES AND TEACHING METHODS, 48, 18-22.
ЯНОВА, Э. У., ИСТАТОВА, Ф. Ш., & АЗИМОВА, А. А. (2023). Морфометрия Коркового Вещества При Церебральной Микроангиопатии. Central Asian Journal of Medical and Natural Science, 4(3), 51-64.
Article Statistics
Downloads
Copyright License

This work is licensed under a Creative Commons Attribution 4.0 International License.