Kidney stones (urolithiasis) are one of the most common diseases of the urinary system and develop under the influence of metabolic, infectious, and environmental factors. The disease may present with pain syndrome, urinary dysfunction, and various complications. This article analyzes the mechanisms of kidney stone formation, risk factors, clinical manifestations, and modern diagnostic and treatment methods.

kidney stone, urolithiasis, nephrolithiasis, urinary system, metabolic disorder, lithotripsy.

Coe, F. L., Evan, A., & Worcester, E. (2005). Kidney stone disease. The Journal of Clinical Investigation, 115(10), 2598–2608. https://doi.org/10.1172/JCI26662

Khan, S. R., Pearle, M. S., Robertson, W. G., Gambaro, G., Canales, B. K., Doizi, S., … Tiselius, H. G. (2016). Kidney stones. Nature Reviews Disease Primers, 2, 16008. https://doi.org/10.1038/nrdp.2016.8

Pearle, M. S., Goldfarb, D. S., Assimos, D. G., Curhan, G., Denu-Ciocca, C. J., Matlaga, B. R., … White, J. R. (2014). Medical management of kidney stones: AUA guideline. The Journal of Urology, 192(2), 316–324. https://doi.org/10.1016/j.juro.2014.05.006

Türk, C., Neisius, A., Petřík, A., Seitz, C., Skolarikos, A., Somani, B., & Thomas, K. (2023). EAU guidelines on urolithiasis. European Association of Urology Guidelines. https://uroweb.org/guidelines/urolithiasis

Worcester, E. M., & Coe, F. L. (2010). Clinical practice: Calcium kidney stones. The New England Journal of Medicine, 363(10), 954–963. https://doi.org/10.1056/NEJMcp1001011

Evan, A. P. (2010). Physiopathology and etiology of stone formation in the kidney and the urinary tract. Pediatric Nephrology, 25(5), 831–841. https://doi.org/10.1007/s00467-009-1116-y

Khan, S. R. (2013). Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: Evidence from clinical and experimental investigations. The Journal of Urology, 189(3), 803–811. https://doi.org/10.1016/j.juro.2012.05.078

Sakhaee, K. (2009). Nephrolithiasis as a systemic disorder. Current Opinion in Nephrology and Hypertension, 18(2), 133–138. https://doi.org/10.1097/MNH.0b013e328325a2c0

Sorokin, I., Mamoulakis, C., Miyazawa, K., Rodgers, A., Talati, J., & Lotan, Y. (2017). Epidemiology of stone disease across the world. World Journal of Urology, 35(9), 1301–1320. https://doi.org/10.1007/s00345-017-2008-6

Taguchi, K., Hamamoto, S., Okada, A., Unno, R., Kamisawa, H., Naiki, T., … Yasui, T. (2018). Genome-wide association study identifies multiple susceptibility loci for nephrolithiasis. Nature Communications, 9, 3395. https://doi.org/10.1038/s41467-018-05853-3

Zhang, Y., Kong, W., & Jiang, Y. (2021). Role of inflammation and oxidative stress in kidney stone formation. Frontiers in Immunology, 12, 742746. https://doi.org/10.3389/fimmu.2021.742746