Articles
| Open Access |
https://doi.org/10.55640/
RELATIONSHIP BETWEEN HEMORRHAGIC SYNDROMES AND ONCOHEMATOLOGICAL DISEASES IN CHILDREN
Pirimova Nasiba Abubakirovna,Xolmurodova Sevinch Ikromjon qizi,Uskinov Samandar Nodirjon o‘g‘li,Mamatqulova Feruza Khaydarovna , 3rd-year student, Faculty of Pediatrics, Samarkand State Medical University,3rd-year student, Faculty of Pediatrics, Samarkand State Medical University,3rd-year student, Faculty of Pediatrics, Samarkand State Medical University,Assistant Department of Pediatric Oncohematology, Samarkand State Medical University Samarkand, UzbekistanAbstract
This article provides a comprehensive analysis of the pathogenetic mechanisms, clinical manifestations, and diagnostic significance of hemorrhagic syndromes in the pediatric population, with particular emphasis on their association with oncohematological diseases. In childhood, hemorrhagic manifestations are commonly attributed to primary hemostatic disorders such as thrombocytopenia, coagulation factor deficiencies, or vascular wall abnormalities. However, in a considerable number of cases, hemorrhagic syndrome may represent an early clinical sign of underlying malignant hematological conditions. The study explores the molecular and cellular mechanisms linking bone marrow dysfunction to the development of hemorrhagic complications. Special attention is given to impaired hematopoiesis, quantitative and qualitative platelet abnormalities, reduced synthesis of coagulation factors, and endothelial dysfunction as central components of the pathophysiological process. Acute lymphoblastic leukemia, acute myeloid leukemia, aplastic anemia, and myelodysplastic syndromes are discussed as major pediatric oncohematological disorders frequently accompanied by bleeding manifestations.
Keywords
hemorrhagic syndrome, pediatric hematology, oncohematological diseases, acute lymphoblastic leukemia, acute myeloid leukemia, thrombocytopenia, coagulation disorders, bleeding complications
References
Kliegman R.M., St. Geme J.W. Nelson Textbook of Pediatrics. 21st ed. Philadelphia: Elsevier; 2020. 2312–2338 p.
Lanzkowsky P., Lipton J.M., Fish J.D. Lanzkowsky’s Manual of Pediatric Hematology and Oncology. 6th ed. London: Academic Press; 2016.145–198 p.
Hoffman R., Benz E.J., Silberstein L.E., et al. Hematology: Basic Principles and Practice. 7th ed. Philadelphia: Elsevier; 2018. 1823–1856 p.
Arber D.A., Orazi A., Hasserjian R., et al. The 2016 revision of the WHO classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391–2405.
Pui C.H., Yang J.J., Hunger S.P., et al. Childhood acute lymphoblastic leukemia: progress and challenges. Lancet. 2019;394(10215):2323–2337.
Levi M., Toh C.H., Thachil J., Watson H.G. Disseminated intravascular coagulation: guidelines for diagnosis and management. Lancet. 2009;373(9671):155–166.
Toshpo‘latov Y.T., Karimov X.K. Bolalar gematologiyasi asoslari. Toshkent: Ibn Sino nomidagi nashriyot; 2018. 124–167 b.
Axmedov A.A., Raximova D.N. Bolalarda qon tizimi kasalliklari. Samarqand: SamDTU nashriyoti; 2021. 89–142 b.
Usmonov Sh.S., Yuldasheva M.T. Klinik gematologiya. Toshkent: Yangi asr avlodi; 2019. 201–256 b.
Young N.S. Aplastic anemia. New England Journal of Medicine. 2018;379(17):1643–1656.
Article Statistics
Downloads
Copyright License
This work is licensed under a Creative Commons Attribution 4.0 International License.