Background. Arterial hypertension remains one of the leading preventable causes of cardiovascular morbidity and mortality worldwide. Despite the availability of effective antihypertensive medications, achieving target blood pressure control is consistently hindered by poor patient adherence to prescribed therapeutic regimens. The objective of this study was to evaluate the baseline level of medical adherence among patients suffering from arterial hypertension and to determine the effectiveness of targeted educational interventions in improving their compliance. Methods. A comprehensive prospective study was conducted at the clinical base of the Faculty Therapy Department of the Andijan State Medical Institute. The study enrolled a total of 71 patients diagnosed with essential arterial hypertension. Baseline adherence was evaluated using the standardized Morisky-Green questionnaire. Following the initial assessment, all participants underwent a structured educational program focused on disease awareness, lifestyle modification, and the critical importance of uninterrupted medication intake. Patients were followed up for six months to evaluate changes in their adherence levels and corresponding clinical outcomes. Results. The initial evaluation revealed that a significant portion of the participants exhibited low adherence to antihypertensive therapy. Specifically, prior to the educational intervention, high adherence was observed in only a minor fraction of the study population. After the implementation of continuous medical counseling and structured educational sessions over the six-month period, a substantial shift was noted. The proportion of patients demonstrating high and medium adherence significantly increased, which was concurrently associated with a statistically significant reduction in both mean systolic and diastolic blood pressure readings across the cohort. Conclusion. Low adherence to antihypertensive therapy is a prevalent issue that directly contributes to suboptimal blood pressure control. The implementation of personalized, continuous educational interventions and active physician-patient communication within the clinical setting significantly improves therapeutic adherence, leading to better clinical outcomes in patients with arterial hypertension.

Arterial hypertension, treatment adherence, patient compliance, Morisky-Green test, educational interventions, antihypertensive therapy, cardiovascular risk.

Burnier, M., & Egan, B. M. (2019). Adherence in hypertension: A review of prevalence, risk factors, impact, and management. Circulation Research, 124(7), 1124-1140.

Chowdhury, R., Khan, H., Heydon, E., Shroufi, A., Fahimi, S., Moore, C., ... & Franco, O. H. (2013). Adherence to cardiovascular therapy: A meta-analysis of prevalence and clinical consequences. European Heart Journal, 34(38), 2940-2948.

Corrao, G., Parodi, A., Nicotra, F., Zambon, A., Merlino, L., Cesana, G., & Mancia, G. (2011). Better compliance to antihypertensive medications reduces cardiovascular risk. Journal of Hypertension, 29(3), 610-618.

Kjeldsen, S. E., Feldman, R. D., Lisheng, L., Mourad, J. J., Chiang, C. E., Zhang, W., ... & Williams, B. (2014). Updated national and international hypertension guidelines: A review of current recommendations. Drugs, 74(17), 2033-2051.

Kronish, I. M., & Ye, S. (2013). Adherence to cardiovascular medications: Lessons learned and future directions. Progress in Cardiovascular Diseases, 55(6), 590-600.

Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., ... & Zannad, F. (2013). 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Journal of Hypertension, 31(7), 1281-1357.

Morisky, D. E., Ang, A., Krousel-Wood, M., & Ward, H. J. (2008). Predictive validity of a medication adherence measure in an outpatient setting. The Journal of Clinical Hypertension, 10(5), 348-354.

Morisky, D. E., Green, L. W., & Levine, D. M. (1986). Concurrent and predictive validity of a self-reported measure of medication adherence. Medical Care, 24(1), 67-74.

Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., ... & Haynes, R. B. (2014). Interventions for enhancing medication adherence. Cochrane Database of Systematic Reviews, (11).

Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., ... & Whelton, P. K. (2018). Hypertension. Nature Reviews Disease Primers, 4(1), 18014.

Sabaté, E. (2003). Adherence to long-term therapies: Evidence for action. World Health Organization.

Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., ... & Schutte, A. E. (2020). 2020 International Society of Hypertension global hypertension practice guidelines. Hypertension, 75(6), 1334-1357.

Vrijens, B., Antoniou, S., Burnier, M., de la Sierra, A., & Volpe, M. (2017). Current situation of medication adherence in hypertension. Frontiers in Pharmacology, 8, 100.

Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., ... & Desormais, I. (2018). 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal, 39(33), 3021-3104.