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https://doi.org/10.55640/
THE ROLE OF GUT MICROBIOTA IN THE PATHOGENESIS AND RECOVERY AFTER ISCHEMIC STROKE
Saida Shavkatova,Xurshida Shukurova , Student, Faculty of Dentistry EMU University, Uzbekistan,Assistant, Department of Preclinical Disciplines Neurologist EMU University, UzbekistanAbstract
Ischemic stroke is a leading cause of morbidity and long-term disability worldwide. Recent research has revealed that the gut microbiota, the diverse community of microorganisms inhabiting the gastrointestinal tract, plays a critical role in stroke pathophysiology and recovery. The gut-brain axis, a bidirectional communication system connecting the gut and the central nervous system (CNS), regulates immune responses, systemic inflammation, neuronal plasticity, and metabolic homeostasis. Dysbiosis, or an imbalance of gut microbiota, is associated with increased infarct size, exacerbated neuroinflammation, and impaired functional recovery. This review provides a comprehensive overview of current evidence linking gut microbiota to ischemic stroke, detailing mechanisms of action, clinical and experimental studies, and potential microbiota-targeted interventions. Understanding these relationships may inform novel therapeutic strategies to improve recovery outcomes in stroke patients.
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