The aim of the study was to identify specific features of hormonal regulation in patients during the post‑COVID period, with a focus on adrenal function, thyroid activity, and metabolism. The study included 62 patients (34 women and 28 men) aged 22 to 64 years, who underwent treatment and rehabilitation for 3–6 months after COVID‑19. Patients were divided into two groups: without steroid therapy (n=32) and with steroid therapy (n=30). Hormonal profile parameters (cortisol, TSH, free T4, HbA1c, HOMA‑IR), carbohydrate and lipid metabolism, as well as instrumental findings were assessed. In patients without steroid therapy, subclinical hypothyroidism, insulin resistance, dyslipidemia, and reduced cortisol levels were more frequently observed. In patients receiving steroid therapy, a more pronounced recovery of the hormonal profile and stabilization of metabolism were noted; however, the risk of secondary adrenal insufficiency persisted. Post‑COVID syndrome is accompanied by significant endocrine disorders, requiring comprehensive monitoring and individualized rehabilitation programs.

COVID‑19, endocrine complications, adrenal glands, thyroid gland, metabolism, thyroid‑stimulating hormone, insulin resistance, dyslipidemia; rehabilitation, graded physical activity.

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