Articles
| Open Access |
https://doi.org/10.55640/
THE INFLUENCE OF VITAMIN D ON THE DEVELOPMENT AND PROGRESSION OF HASHIMOTO'S GOITER: A COMPREHENSIVE ANALYSIS OF CLINICAL AND IMMUNOLOGICAL ASPECTS
Abubakirov R.Kh., Madumarova M.M., Aysacheva M.O., Yusupova Sh.K. , Student, Andijan Branch of Kokand University, Student, Andijan Branch of Kokand University, Assistant Professor, Department of Normal and Pathological Physiology, Andijan Branch of Kokand University, Associate Professor, Head of the Department of Hospital Therapy and Endocrinology, Andijan State Medical InstituteAbstract
This article presents a descriptive review of the literature on the role of vitamin D in the pathogenesis of autoimmune thyroiditis (Hashimoto's goiter). The mechanisms of extrarenal calcitriol synthesis by immune cells and its effect on T-lymphocyte differentiation are discussed. The results of epidemiological and interventional clinical studies demonstrating an inverse relationship between serum 25(OH)D levels and antithyroid autoantibody titers are analyzed. The clinical significance of monitoring vitamin D status and its targeted supplementation as a pathogenetic adjuvant therapy for this disease is substantiated.
Keywords
autoimmune thyroiditis, Hashimoto's thyroiditis, vitamin D, calcitriol, immunomodulation, T-helper cells, autoantibodies.
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