Articles
| Open Access |
https://doi.org/10.55640/
THE ROLE OF ZINC IN ENDOCRINE-IMMUNE REGULATION IN THYROID DYSFUNCTION
Gulomov Zh.M., Ibrokhimova G.U., Madumarova M.M., Aysacheva M.O., Yusupova Sh.K. , Student, Andijan Branch of Kokand University, Student, Andijan Branch of Kokand University, Student, Andijan Branch of Kokand University, Assistant Professor, Department of Normal and Pathological Physiology, Andijan Branch of Kokand University, Associate Professor, Head of the Department of Hospital Therapy and Endocrinology, Andijan State Medical InstituteAbstract
This review explores the role of zinc in endocrine-immune regulation with a particular focus on thyroid dysfunction. Zinc is an essential trace element involved in numerous biological processes, including hormone synthesis, immune response modulation, and antioxidant defense. In thyroid physiology, zinc contributes to the regulation of thyroid hormone production and receptor function. Deficiency of zinc has been associated with impaired immune responses, increased oxidative stress, and altered thyroid hormone metabolism, potentially contributing to conditions such as hypothyroidism and autoimmune thyroid diseases. Furthermore, zinc plays a critical role in maintaining the balance between pro-inflammatory and anti-inflammatory mechanisms. Understanding the interaction between zinc status and thyroid function may provide new perspectives for prevention and supportive treatment strategies in endocrine disorders.
Keywords
zinc; thyroid dysfunction; endocrine regulation; immune system; hypothyroidism; autoimmune thyroid disease; trace elements; oxidative stress; inflammation; hormone metabolism.
References
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Paulazo MA, Klecha AJ, Sterle HA, Valli E., Torti H., Cayrol MF, Barreiro Arcos ML, Cremaschi GA Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity. Endocrine, 2019.
1 Paulazo MA, Klecha AJ, Sterle HA, Valli E., Torti H., Cayrol MF, Barreiro Arcos ML, Cremaschi GA Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity. Endocrine, 2019.
Beserra JB, Morais JBS, Severo JS, Cruz KJC, de Oliveira ARS, Henriques GS, do Nascimento Marreiro D. Relation between Zinc and Thyroid Hormones in Humans: a Systematic Review. Biological Trace Element Research, 2021.
Shulhai A.-M., Rotondo R., Petraroli M., Patianna V., Predieri B., Iughetti L., Esposito S., Street ME The Role of Nutrition on Thyroid Function. Nutrients, 2024.
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