Salivary gland involvement in viral infections represents an important clinical manifestation that often reflects systemic disease processes. Viruses such as mumps virus, cytomegalovirus (CMV), Epstein–Barr virus (EBV), and more recently SARS-CoV-2 demonstrate tropism for salivary gland tissue, leading to inflammation, dysfunction, and characteristic clinical symptoms. This study aims to analyze the clinical features of salivary gland diseases associated with viral infections through a comprehensive clinical and analytical approach. A mixed-methods study involving 98 patients diagnosed with viral-associated salivary gland disorders between 2020 and 2025 was conducted. Quantitative analysis included symptom prevalence, duration, and complication rates, while qualitative assessment focused on clinical presentation patterns and patient-reported experiences. The results indicate that acute viral sialadenitis is characterized by rapid onset, glandular swelling, pain, and systemic symptoms, while chronic or latent viral infections may lead to persistent dysfunction and xerostomia. The study highlights the importance of early recognition and differential diagnosis to prevent complications and optimize patient care in viral salivary gland pathology.

viral infections, salivary glands, sialadenitis, mumps, cytomegalovirus, Epstein–Barr virus, SARS-CoV-2, xerostomia, glandular swelling, inflammation, clinical features, diagnosis, head and neck pathology

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