Articles
| Open Access |
https://doi.org/10.55640/
AEROBIC GLYCOLYSIS IN CANCER CELLS (THE WARBURG EFFECT): BIOCHEMICAL MECHANISMS AND THERAPEUTIC IMPLICATIONS
Azamatov Asadbek Ilhom ugli,Rustamova Sevarakhon Farkhod kizi,Karimova Kamola Askar kizi,Abdihalimova Dilfuza Ruyiddin kizi,Yuldosheva Mohira Abdurakhmonovna , Tashkent State Medical University, Termez Branch Students of the Faculty of General MedicineAbstract
Cancer cells exhibit a peculiar metabolic phenotype known as aerobic glycolysis or the Warburg effect, where they preferentially convert glucose to lactate even in the presence of sufficient oxygen. This review outlines the biochemical foundations of this phenomenon, contrasting it with normal oxidative phosphorylation. We discuss the key enzymatic shifts (e.g., increased hexokinase 2, pyruvate kinase M2, and LDHA), the role of oncogenes (c-Myc, HIF-1α) and tumor suppressors (p53), and the resulting metabolic advantage for rapid proliferation. Finally, we highlight potential therapeutic strategies targeting this pathway.
Keywords
Warburg effect, aerobic glycolysis, cancer metabolism, lactate, hexokinase 2, PKM2, HIF-1α, tumor microenvironment.
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