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| Open Access |
https://doi.org/10.55640/
BILIRUBIN METABOLISM AND PATHOMORPHOLOGICAL CHANGES IN THE HEPATOBILIARY SYSTEM IN ITS DISORDERS
Normuminova Dilnoza Yulchi qizi,Ashurova Maftuna Yusuf qizi,Oxunova Fotimaxon Abbosxon qizi,Razokova Shaxodat Rasulovna , Student of group 209, Faculty of Pediatrics 2, Medical Biology and Fundamental Medicine, Tashkent State Medical University, Master's student, Faculty of Literary Studies: English Literature, UzSWLU,Student of group 209, Faculty of Pediatrics 2, Medical Biology and Fundamental Medicine, Tashkent State Medical University Scientific supervisor,Assistant of the Department of Medical Informatics and Biophysics, Medical Biology, Medical and Biological Chemistry, TSMUAbstract
bilirubin metabolism is one of the important stages of heme metabolism in the human body. Bilirubin is mainly formed as e result of the breakdown of erythrocytes, and it’s subsequent biochemical transformations are closely related to liver function. Under normal conditions, bilirubin is processed in the liver and excreted from the body through bile. Any disturbance occurring at any stage of this complex process leads to an increase in bilirubin levels in the body, that is, hyperbilirubinemia. Disorders of bilirubin metabolism have a direct impact on the structural and functional state of the hepatobiliary system – the liver and bile ducts. As a result, various pathomorphological changes are observed in this system, including damage to hepatocytes, bile stasis ( cholestasis), and occumulation of pigments in tissues. These changes lead not only to impairment of liver function but also to disruption of metabolic processes throughout the body.
The aim of this article is to study and analyze the pathomorphological changes occurring in the hepatobiliary system as aresult of disorders in bilirubin metabolism
Keywords
bilirubin, hyperbilirubinemia, hepatobiliary system, cholestasis, jaundice, liver diseases.
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