Articles
| Open Access |
https://doi.org/10.55640/
MORPHOLOGICAL EVALUATION OF PROLIFERATION, APOPTOSIS, AND ANGIOGENESIS PROCESSES IN CERVICAL NEOPLASIAS BASED ON IHC MARKERS (ON THE EXAMPLE OF SURKHANDARYA REGION)
Musulmonova Hilola Safarmurodovna,Turdimuratov Baxtiyor Kurbonovich,Rustamova Durdona Homid qizi,Ashurova Aziza Ortiqjon qizi , Assistant, Department of Anatomy and Clinical Anatomy,Teacher, Department of Social and Humanitarian Sciences Tashkent State Medical University, Termez Branch,1st-year student, Faculty of Pediatrics (Major: Pediatrics), Tashkent State Medical University, Termez Branch ,1st-year student, Faculty of Pediatrics (Major: Pediatrics), Tashkent State Medical University, Termez BranchAbstract
This study morphologically evaluated the immunohistochemical (IHC) changes in proliferation (Ki-67), apoptosis (p53), and angiogenesis (VEGF, CD31) processes during the development of cervical epithelial neoplasias (CIN I, II, III) and squamous cell carcinoma, using the population of the Surkhandarya region as an example. The results showed that as the degree of dysplasia increases, Ki-67 expression and microvessel density (MVD) reliably increase, while the accumulation of the p53 protein indicates a disruption of the apoptosis process. This complex of markers is of great importance for the early detection and prognostic assessment of at-risk patients in regional conditions.
Keywords
Cervical neoplasia, CIN, immunohistochemistry, Ki-67, p53, VEGF, angiogenesis, proliferation, Surkhandarya region.
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