Maxillofacial reconstruction represents one of the most complex areas of modern surgery due to the functional and aesthetic importance of facial structures. Conventional reconstructive techniques, although effective, are often limited by donor site morbidity, insufficient tissue compatibility, and incomplete functional restoration. Regenerative medicine and tissue engineering have emerged as innovative approaches aimed at restoring damaged tissues through biological regeneration rather than replacement. This study aims to analyze the role of regenerative medicine and tissue engineering in maxillofacial reconstruction and evaluate their clinical applications and future potential. A review of recent literature and clinical studies (2015-2025) was conducted. The findings demonstrate that stem cell therapy, biomaterials, 3D bioprinting, and growth factor-based approaches significantly enhance bone and soft tissue regeneration. The integration of these technologies into clinical practice offers promising results in restoring facial structure and function. The study emphasizes the transformative potential of regenerative strategies in maxillofacial surgery.

regenerative medicine, tissue engineering, maxillofacial reconstruction, stem cells, biomaterials, 3D bioprinting, bone regeneration, growth factors, craniofacial surgery

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