Burn injuries remain a significant clinical challenge due to prolonged healing time, high risk of infection, and excessive scar formation. The present study evaluates the therapeutic effectiveness of a 6-aminopurine–based moisture-forming hydrogel in the treatment of burn wounds. The hydrogel matrix was designed to provide a stable moist microenvironment, controlled release of the bioactive compound, and enhanced tissue regeneration. Physicochemical properties of the hydrogel, including swelling capacity, mechanical stability, and release kinetics of 6-aminopurine, were investigated. In vitro and in vivo assessments demonstrated that the hydrogel promotes epithelialization, reduces inflammatory response, and accelerates granulation tissue formation compared to conventional dry dressings. The controlled release profile ensured sustained biological activity at the wound site while minimizing systemic exposure. Histological analysis confirmed improved collagen organization and reduced necrotic tissue formation. The results indicate that 6-aminopurine–loaded hydrogels represent a promising therapeutic approach for burn wound management by combining moisture balance, regenerative stimulation, and anti-inflammatory effects.

6-Aminopurine; Hydrogel therapy; Burn wounds; Moist wound healing; Controlled release; Tissue regeneration; Anti-inflammatory activity; Wound management.

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