Articles
| Open Access |
https://doi.org/10.55640/
ARTIFICIAL TISSUES AND TISSUE ENGINEERING: MODERN ADVANCES AND PERSPECTIVES
Ergashev Mirzohid Adham ugli,Xolmurodov Shaxriyor Dilshod ugli,Turdimuratov Baxtiyor Kurbonovich,Joʻrayeva Samiya Hasanovna , 1st-year Student, Pediatrics Faculty Termez Branch of Tashkent Medical Academy,1st-year Student, Pediatrics Faculty Termez Branch of Tashkent Medical Academy,Teacher, Department of Social and Humanitarian Sciences Tashkent State Medical University, Termez Branch,Assistant, Department of Medical Biology and Histology Termez Branch of Tashkent Medical AcademyAbstract
This article analyzes the theoretical and practical foundations of tissue engineering, one of the priority directions in modern regenerative medicine. The purpose of this study is to evaluate the effectiveness of artificial matrices (scaffolds), mesenchymal stem cells, and bioreactor technologies used in repairing damaged tissues. The study investigated 3D frameworks based on polymeric materials and factors regulating cell differentiation using histological and biotechnological methods. The results indicate that properly selected matrix structures significantly activate cell proliferation and angiogenesis processes. However, challenges such as vascularization and immunological rejection remain critical issues for the clinical implementation of tissue engineering. The conclusion emphasizes that the development of 3D bioprinting technologies will be a key solution to overcoming donor shortages in organ transplantation in the near future.
Keywords
Tissue engineering, regenerative medicine, mesenchymal stem cells, 3D bioprinting, vascularization, biocompatibility.
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