Articles | Open Access | https://doi.org/10.55640/

GRIERSON-GOPALAN SYNDROME: A COMPREHENSIVE NARRATIVE REVIEW OF BURNING FEET SYNDROME

Dr Aman Khandelwal , Assistant Teacher, Samarkand state medical university, Uzbekistan Aman3238@gmail.com
JV Glory , Medical Student, Samarkand state medical university, Uzbekistan
Bengia Kartik , Bengia Kartik Medical Student, Samarkand state medical university

Abstract

Imagine lying in bed at night, ready to surrender to sleep, only to be met with an unrelenting sensation that your feet are on fire. The sheets feel unbearably hot, the cool air of the room offers no relief, and no position seems to quiet the gnawing heat radiating from the soles upward. For millions of individuals worldwide, this is not a fleeting discomfort but a chronic, often misunderstood reality. This condition—clinically recognized as Burning Feet Syndrome (BFS) or Grierson-Gopalan syndrome—represents one of the most distressing yet underdiagnosed manifestations of peripheral nerve dysfunction .

Keywords

Grierson-Gopalan syndrome, burning feet syndrome, peripheral neuropathy, small fiber neuropathy, diabetic neuropathy, paresthesia, podiatry, neuralgia, vitamin B12 deficiency, nociception

References

https://www.webmd.com/diabetes/burning-feet-causes-treatments

Physiopedia. Grierson-Gopalan Syndrome. Available at: https://www.physio-pedia.com/Grierson-Gopalan_Syndrome

Bala V. Systematic Literature Review on Burning Feet Syndrome. Journal of Brain and Neuroscience Research (2025). Available at: https://www.heraldopenaccess.us/openaccess/systematic-literature-review-on-burning-feet-syndrome

Rela Institute. Burning Feet Syndrome: Causes, Symptoms, and Treatment. (2026). Available at: https://www.relainstitute.com/articles/burning-feet-syndrome-causes-symptoms-and-treatment/

Ankle & Foot MD. Understanding Burning Feet Syndrome. (2020). Available at: https://www.anklefootmd.com/understanding-burning-feet-syndrome/

Cleveland Clinic. Burning Feet Syndrome. (2023). Available at: https://my.clevelandclinic.org/health/symptoms/17773-burning-feet-syndrome

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GRIERSON-GOPALAN SYNDROME: A COMPREHENSIVE NARRATIVE REVIEW OF BURNING FEET SYNDROME. (2026). International Journal of Medical Sciences, 6(4), 640-650. https://doi.org/10.55640/