This research paper aims to scientifically and theoretically analyze the pathophysiological mechanisms of stressor agents on the human organism, specifically the morphofunctional transformations occurring in the neuroendocrine regulation, cardiovascular, and immune systems. The article elucidates the activation of the hypothalamic-pituitary-adrenal (HPA) axis during acute and chronic stress, as well as the destructive effects of catecholamine and glucocorticoid secretion on organ tissues within the framework of modern clinical and histological approaches. The research findings serve to understand the etiology of psychosomatic diseases, optimize the diagnostic process, and enhance the effectiveness of rehabilitative measures in preventive medicine.

stress response, neuroendocrine system, hypothalamic-pituitary-adrenal axis, cortisol, psychosomatics, homeostasis, allostatic load, adaptation syndrome.

Selye, H. (1920). Stress in Health and Disease. Butterworth-Heinemann. (Fundamental basis of stress theory).

Qurbonov, Sh. Q., et al. (2023). Human Anatomy and Histology: Morphology of Nervous and Connective Tissues [In Uzbek]. Tashkent: "Ibn Sino" Publishing House.

Mamatova, L. B., & Karimov, R. J. (2024). Specific histological features of parenchymal organs (kidney and liver) against the background of chronic toxic hepatitis [In Uzbek]. Uzbek Medical Journal, 2(14), 45-52.

Smith, S. M., & Vale, W. W. (2025). The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues in Clinical Neuroscience, 28(1), 14-25.

Abu Ali ibn Sina (Avicenna). (1996). The Canon of Medicine (Vol. I) [In Uzbek translation]. Tashkent: Abdulla Qodiriy National Heritage Publishing House. (Unity of mind and body in ancient Eastern medicine).

Tursunov, Y. E. (2022). History of Medicine and Bioethics: Philosophical Aspects of Doctor-Patient Relationships [In Uzbek]. Samarkand: SamSMU Publishing House.

Axmedov, F. M. (2025). Information Technologies in Medical Education: Methodology of Statistical Processing of Clinical Analyses in the Microsoft Excel Environment [In Uzbek]. Tashkent: "Tafakkur" Publishing House.

McEwen, B. S. (2021). Neurobiological and Systemic Effects of Chronic Stress: Allostatic Load and Clinical Implications. Journal of Psychosomatic Research, 115, 10-18.

Abdurahmonov, A. A. (2024). Medical deontology and prevention of psychosomatic diseases [In Uzbek]. Medicine and Time, 4(112), 77-83.

Gartner, L. P., & Hiatt, J. L. (2022). Color Textbook of Histology (4th ed.). Elsevier. (For international histological and morphometric standards).

Kurbonovich, T. B. et al. (2025). DIGITAL TECHNOLOGIES IN MEDICINE. TELEMEDICINE. IMRAS. Vol. 8. No. 12. P. 39-41.

Kurbonovich, T. B. et al. (2026). PROBLEMS IN MODERN CULTURE: SOCIO-SPIRITUAL ANALYSIS IN THE CONTEXT OF GLOBALIZATION AND DIGITAL TRANSFORMATION. Global Science Review. Vol. 18. No. 1. P. 183-188.

Kurbonovich, T. B..et al. (2026). REGENERATIVE PROPERTIES AND MODERN HISTOLOGICAL ANALYSIS OF CONNECTIVE TISSUE IN THE MORPHOFUNCTIONAL SYSTEM OF THE ORGANISM. American Journal of Applied Medical Science. Vol. 4. No. 2. P. 230-235.

Turdimuratov, B.K. (2022). Teaching Medical Sciences Using Innovative Methods and ICT. Tashkent: Uzbekistan Medical Publishing House.

Kurbonovich, T.B, & Bahodirovich, B.B. (2026). Step-by-step acquisition of practical skills in studying information technologies in medicine. Global Science Review, 17(1), 203–209.

Kurbonovich, T.B., & Nurhayat, M. (2026). Compilation and steps of the medical situational issues algorithm. American Journal of Applied Medical Science, 4(2), 59–63.

Turdimurodov, B.K., et al. The essence of electronic textbooks in medical education. European Journal of Humanities and Educational Advancements, 3(4), 48–50.

Kurbonovich, T. B. (2026). MODERN CARDIAC SURGERY: EVOLUTIONARY MILESTONES AND CLINICAL RELEVANCE. American Journal of Applied Medical Science. Vol. 4. No. 3. P. 56-58.