Articles
| Open Access |
https://doi.org/10.5281/zenodo.20040823
KNOWLEDGE, CLINICAL ATTITUDES, AND PERCEIVED BARRIERS TOWARD LIQUID BIOPSY AND MULTI-CANCER EARLY DETECTION (MCED): A COMPARATIVE CROSS-SECTIONAL ANALYSIS BETWEEN MEDICAL STUDENTS AND FACULTY
Samir Basha, Mohammed Fayaz, K. Mohamed Mustaq , Medical Student, Samarkand state medical university, UzbekistanAbstract
Multi-cancer early detection (MCED) tests represent a transformative frontier in oncology, leveraging blood-based liquid biopsy technologies to screen for multiple malignancies through a single non-invasive assay. Despite rapid technological advancement, the integration of MCED concepts into medical education remains poorly characterized. This study examined knowledge levels, clinical attitudes, and perceived implementation barriers toward liquid biopsy and MCED among medical students and faculty at a large academic medical center.
Keywords
liquid biopsy, multi-cancer early detection, MCED, medical education, cancer screening, health professions education, comparative cross-sectional study
References
National Cancer Institute. Cancer Statistics. Bethesda, MD: National Institutes of Health; 2025.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2025. CA: A Cancer Journal for Clinicians. 2025;75(1):10-45.
Cristiano S, Leal A, Phallen J, et al. Genome-wide cell-free DNA fragmentation in patients with cancer. Nature. 2019;570(7761):385-389.
Papanastasiou AP, et al. Comparison of liquid biopsy-based technologies for cancer screening. Critical Reviews in Clinical Laboratory Sciences. 2025.
Liu G, et al. Cancer patient-reported preferences and knowledge for liquid biopsies and blood biomarkers at a comprehensive cancer center. Patient Preference and Adherence. 2020;14:367-378.
OncLive. Multicancer Early Detection Testing: a Population-Based Screening Strategy? April 2026.
Klein EA, Richards D, Cohn A, et al. Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set. Annals of Oncology. 2021;32(9):1167-1177.
Schrag D, et al. Perspectives on clinical adoption barriers to blood-based multi-cancer early detection tests across stakeholders. BMC Health Services Research. 2023;23:1120.
Papanastasiou AP, et al. Comparison of liquid biopsy-based technologies for cancer screening. Critical Reviews in Clinical Laboratory Sciences. 2025.
American Association for Cancer Research. Liquid biopsies spark hope for early cancer detection. December 2025.
National Cancer Institute. SEER Cancer Statistics Review, 1975-2022. Bethesda, MD: National Cancer Institute; 2025.
Health Information National Trends Survey. Multi-Cancer Early Detection Tests: National Estimates of Awareness and Perceived Value. medRxiv. August 2025.
U.S. Preventive Services Task Force. Screening for cancer: USPSTF recommendation statements. JAMA. 2024.
Institute of Medicine. Improving Medical Education: Enhancing the Behavioral and Social Science Content of Medical School Curricula. Washington, DC: National Academies Press; 2024.
Epstein RM, Street RL. The values and value of patient-centered care. Annals of Family Medicine. 2011;9(2):100-103.
Article Statistics
Downloads
Copyright License
This work is licensed under a Creative Commons Attribution 4.0 International License.