Articles | Open Access | https://doi.org/10.55640/

PSYCHOSOMATIC DISEASES AND THE IMPACT OF EMOTIONAL STRESS ON THE HUMAN ORGANISM

Ruzimatova Gulnozakhon Mukhidin kizi , Student, Andijan State Medical Institute

Abstract

This article examines the influence of emotional stress on the development and progression of psychosomatic diseases. Modern scientific studies confirm that chronic emotional stress affects the nervous, endocrine, immune, and cardiovascular systems, thereby contributing to the emergence of psychosomatic disorders. The article analyzes the physiological mechanisms of stress, the role of cortisol and catecholamines, and the relationship between psychological factors and somatic pathology. Particular attention is paid to diseases such as hypertension, bronchial asthma, peptic ulcer disease, irritable bowel syndrome, and dermatological disorders. The paper also discusses diagnostic approaches, preventive strategies, and psychotherapeutic interventions aimed at reducing psychosomatic manifestations. The study is based on evidence from international scientific literature and clinical observations.

Keywords

Psychosomatic diseases, emotional stress, cortisol, autonomic nervous system, психophysiology, hypertension, anxiety, depression, immune system, psychosomatic medicine, chronic stress, neuroendocrine mechanisms.

References

Lipowski ZJ. Psychosomatic medicine: past and present. Canadian Journal of Psychiatry. 2000;45(2):135–143. pp. 136–139.

World Health Organization. Mental health and stress-related disorders report. Geneva: WHO; 2021. pp. 22–28.

McEwen BS. Protective and damaging effects of stress mediators. New England Journal of Medicine. 1998;338(3):171–179. pp. 172–176.

Chrousos GP. Stress and disorders of the stress system. Nature Reviews Endocrinology. 2009;5(7):374–381. pp. 375–378.

Kiecolt-Glaser JK, et al. Psychoneuroimmunology and psychosomatic medicine. Psychosomatic Medicine. 2002;64(1):15–28. pp. 18–22.

Sapolsky RM. Why Zebras Don’t Get Ulcers. 3rd ed. New York: Holt Paperbacks; 2004. pp. 25–48.

Guyton AC, Hall JE. Textbook of Medical Physiology. 14th ed. Philadelphia: Elsevier; 2021. pp. 921–930.

Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis and stress. Journal of Psychosomatic Research. 2002;53(4):865–871. pp. 866–869.

Black PH, Garbutt LD. Stress, inflammation, and cardiovascular disease. Journal of Psychosomatic Research. 2002;52(1):1–23. pp. 5–12.

Thayer JF, Lane RD. The role of vagal function in stress regulation. Biological Psychology. 2000;74(2):224–242. pp. 228–233.

Rozanski A, et al. Impact of psychological factors on cardiovascular disease. Circulation. 2005;99(16):2192–2217. pp. 2198–2205.

Steptoe A, Kivimäki M. Stress and cardiovascular disease. Nature Reviews Cardiology. 2012;9(6):360–370. pp. 362–366.

Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut. 2000;47(6):861–869. pp. 863–866.

Drossman DA. Functional gastrointestinal disorders. Gastroenterology. 2016;150(6):1262–1279. pp. 1268–1271.

Lehrer PM, et al. Psychological aspects of asthma. Journal of Consulting and Clinical Psychology. 2002;70(3):691–711. pp. 694–700.

Kimyai-Asadi A, Usman A. The role of psychological stress in skin disease. Journal of Cutaneous Medicine. 2001;5(2):140–145. pp. 141–143.

Cohen S, et al. Psychological stress and susceptibility to infectious disease. New England Journal of Medicine. 1991;325(9):606–612. pp. 607–610.

Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction. Nature Reviews Immunology. 2005;5(3):243–251. pp. 245–247.

Engel GL. The need for a new medical model. Science. 1977;196(4286):129–136. pp. 130–133.

Selye H. The Stress of Life. New York: McGraw-Hill; 1976. pp. 55–70.

Fink G. Stress physiology and pathophysiology. Handbook of Stress Science. 2016;1(1):3–15. pp. 6–10.

Lupien SJ, et al. Effects of stress throughout the lifespan on the brain. Nature Reviews Neuroscience. 2009;10(6):434–445. pp. 437–441.

Charmandari E, et al. Endocrinology of the stress response. Annual Review of Physiology. 2005;67:259–284. pp. 264–269.

Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder. Psychological Bulletin. 2014;140(3):774–815. pp. 780–789.

Yusuf S, et al. Effect of psychosocial factors in acute myocardial infarction. Lancet. 2004;364(9438):953–962. pp. 955–959.

Carabotti M, et al. The gut-brain axis. Annals of Gastroenterology. 2015;28(2):203–209. pp. 204–206.

Wright RJ. Stress and asthma. Clinical Chest Medicine. 2012;33(3):473–489. pp. 476–481.

Katon W. Depression and chronic medical illness. Journal of Clinical Psychiatry. 2011;72(8):e33. pp. 2–5.

Hofmann SG, et al. The effect of mindfulness-based therapy on anxiety and depression. Journal of Consulting and Clinical Psychology. 2010;78(2):169–183. pp. 171–177.

Schneiderman N, et al. Stress and health: psychological, behavioral, and biological determinants. Annual Review of Clinical Psychology. 2005;1:607–628. pp. 612–620.

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PSYCHOSOMATIC DISEASES AND THE IMPACT OF EMOTIONAL STRESS ON THE HUMAN ORGANISM. (2026). International Journal of Medical Sciences, 6(5), 461-467. https://doi.org/10.55640/