Rheumatoid arthritis in women is characterized by a more severe course of the pathological process, and the lesion of individual joints depends on the gender of patients (in men, changes in the sacroiliac joints, the development of tendovaginitis, intra-articular Goff bodies are more often noted, and in women — the proximal interphalangeal joints of the fingers of the upper and lower extremities, maxillary and knee joints). There is a sexual dimorphism of the integral extraarticular (systemic) manifestations of rheumatoid arthritis, while men have more frequent lung damage and the peripheral nervous system, and exclusively in the female group — Sjogren's syndrome and changes from the central nervous system. In patients with rheumatoid arthritis, the parameters of bone metabolism in the blood serum change, in addition, in patients with osteoporosis, there are common and gender differences in the concentrations of osteoassociated hormones and chemical elements.

rheumatoid arthritis, course, men, women.

Ziyadullaev, S. K., Sultonov, I. I., Dushanova, G. A., & Akbarovna, K. S. (2021). The Effectiveness Of Pharmacotherapy For Dmards With Ra Depending On The C3435t Polymorphism Of The Mdr1 Gene. Int. J. of Aquatic Science, 12(3), 2908-2916.

Ilkhom, S. (2023). CAJAM–VOLUME 1. ISSUE 1. 2023. Central Asian Journal of Advanced Medicine, 1(01), 16-19.

Тоиров, А. Э., Султонов, И. И., & Тоиров, Э. С. (2020). ЗНАЧЕНИЕ ДИСФУНКЦИИ ПОЧЕК У БОЛЬНЫХ ОСТРЫМ ИНФАРКТОМ МИОКАРДА НА ФОНЕ САХАРНОГО ДИАБЕТА 2-ГО ТИПА. Вестник науки и образования, (9-3 (87)), 86-91.

Хамраева, Н. А., Султонов, И. И., & Хасанов, Ф. Ш. У. (2019). Кожные проявления у больных системной красной волчанкой. Вопросы науки и образования, (28 (77)), 128-131.

Khusainova, M. A., Vakhidov, J. J., Khayitov, S. M., & Mamadiyorova, M. M. (2023). Cardiac arrhythmias in patients with rheumatoid arthritis. Science and Education, 4(2), 130-137.

Khusainova, M. A. (2023). Comorbidity thyrotoxicosis with coronary heart disease. Science and Education, 4(5), 205-213.

Khusainova, M. A., Eshmamatova, F. B., Ismoilova, K. T., & Mamadiyorova, M. M. (2023). METABOLIC SYNDROME IN RHEUMATOID ARTHRITIS AS A CRITERION OF CARDIOVASCULAR RISK. Oriental renaissance: Innovative, educational, natural and social sciences, 3(1), 331-339.

Khusainova, M. A., Khaydarov, S. N., Makhmudova, K. D., & Nayimov, A. S. (2023). Prevalence of bronchiolitis in patients with Rheumatoid arthritis. Science and Education, 4(5), 232-241.

Alisherovna, K. M., Ismatullayevich, M. A., & Nuriddinovna, E. N. (2024). FEATURES OF HEART FAILURE IN PATIENTS WITH CORONARY HEART DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 52-61.

Alisherovna, K. M., Yaxshiboyevich, U. M. R., & Yigitaliyevich, B. A. (2024). EVALUATION OF A NATRIURETIC PEPTIDE TO OPTIMIZE THE MANAGEMENT OF COMORBID PATIENTS WITH THYROTOXICOSIS AND HEART FAILURE. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 62-70.

Alisherovna, K. M., Mansurovna, M. D., Erkinovna, N. D., Farxodovna, X. R., Toxirovna, M. M., Tolibovna, R. D., & Yorkinovna, E. N. (2024). ARTERIAL HYPERTENSION AND THYROID STATUS IN PATIENTS OF DIFFERENT AGES. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 122-129.

Alisherovna, K. M., Erkinovna, S. D., Duskobilovich, B. S., & Samandarovich, T. H. (2024). ARTERIAL HYPERTENSION IN THYROTOXICOSIS AND REMODELING OF THE LEFT VENTRICLE OF THE HEART. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 114-121.

Alisherovna, K. M., Boymamatovna, E. F., Tursunboyevna, I. K., & Mashrabovna, M. M. METABOLIC SYNDROME IN RHEUMATOID ARTHRITIS AS A CRITERION OF CARDIOVASCULAR RISK.

Alisherovna, K. M., Habibulloyevna, I. M., & Voxidovna, R. F. (2024). STRUCTURAL AND FUNCTIONAL FEATURES OF THE LEFT VENTRICLE IN PATIENTS WITH HEART FAILUREIN ISCHEMIC HEART DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 71-81.

Alisherovna, K. M., Akramovna, I. K., & Kairatovna, R. A. (2024). THE EFFECTIVENESS OF TREATMENT OF PATIENTS WITH OSTEOARTHRITIS WITH CARDIOVASCULAR DISORDERS IN METABOLIC SYNDROME. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 223-230.

Alisherovna, K. M., Akramovna, I. K., & Yorkinovna, E. N. (2024). CLINICAL AND MORPHOLOGICAL CRITERIA OF COLITIS IN PATIENTS WITH CHRONIC ISCHEMIC DISEASE OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 18(6), 6-13.

Alisherovna, K. M., Akramovna, I. K., Bakhtiyorovich, U. J., Nizamitdinovich, K. S., Jasurovna, J. S., Kairatovna, R. A., & Abdukholikovna, E. S. (2023). Exacerbations of chronic obstructive pulmonary disease and coronary atherosclerosis. Journal of new century innovations, 39(1), 176-178.

Akramovna, I. K., & Alisherovna, K. M. (2024). CAUSES OF ARRHYTHMIA DURING PREGNANCY. Journal of new century innovations, 45(3), 34-41.

Alisherovna, K. M., Akramovna, I. K., & Baxtiyorovna, O. K. (2024). THE COURSE OF CHRONIC ISCHEMIC PANCREATITIS IN PATIENTS WITH CORONARY HEART DISEASE. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 231-239.

Davranovna, M. K. D. K., Alisherovna, K. M., & Erkinovna, K. Z. (2024). CARDIAC ARRHYTHMIAS IN PATIENTS WITH RHEUMATOID ARTHRITIS. Spectrum Journal of Innovation, Reforms and Development, 26, 65-71.

Erkinovna, K. Z., Alisherovna, K. M., & Davranovna, M. K. (2024). ARTERIAL HYPERTENSION AND ARRHYTHMIA. Spectrum Journal of Innovation, Reforms and Development, 26, 72-78.

Alisherovna, K. M., Davranovna, M. K., & Erkinovna, K. Z. (2024). Coronary heart disease and osteoporosis in postmenopausal women. Spectrum Journal of Innovation, Reforms and Development, 26, 40-45.

Nizamitdinovich, K. S., Alisherovna, K. M., & Erkinovna, K. Z. (2024). ASSESSMENT OF THE RISK OF DEVELOPING DIABETES MELLITUS FOR MEN. Spectrum Journal of Innovation, Reforms and Development, 26, 114-123.

Alisherovna, K. M., Nizamitdinovich, K. S., & Erkinovna, K. Z. (2024). THE EFFECTIVENESS OF BISOPROLOL AND METFORMIN IN ARTERIAL HYPERTENSION AND METABOLIC SYNDROME. Spectrum Journal of Innovation, Reforms and Development, 26, 106-113.

Sheraliyevich, X. F., & Farhod o’g, Z. O. A. (2024). JIGAR SERROZINI ANIQLASHDA INNOVATSION YECHIM. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 43(1), 3-10.

Sheraliyevich, X. F. (2024). O’PKA ABSESI VA GANGRENASI. Journal of new century innovations, 46(2), 152-153.

Sheralievich, K. F. (2024). RHEUMATOID ARTHRITIS CAUSES, DIAGNOSIS AND PERIODS. Web of Medicine: Journal of Medicine, Practice and Nursing, 2(9), 50-52.

Sheraliyevich, K. F. (2024). PSYCHOSOMATIC SYMPTOMS IN PATIENTS WITH LIMITED SCLERODERMA. International journal of medical sciences, 4(05), 273-280.

Sheraliyevich, K. F. (2024). PSYCHOMETRIC ASSESSMENT OF THE QUESTIONNAIRE TO STUDY THE ACTIVITY OF SYSTEMIC LUPUS ERYTHEMATOSUS. International journal of medical sciences, 4(05), 266-272.

Yarmatov, S., Khusainova, M., & Djabbarova, N. (2023). STUDY OF QUALITY OF LIFE INDICATORS IN PATIENTS WITH CORONARY HEART DISEASE USING THE SF-36 QUESTIONNAIRE. Бюллетень студентов нового Узбекистана, 1(7), 58-64.