Articles
| Open Access |
https://doi.org/10.55640/
INFLUENCE OF EXTERNAL FACTORS ON THE DEVELOPMENT OF THE AORTA; MAJOR CONGENITAL DEFECTS (COARCTATION)
Kibriyeva Mahfirat Abduraxmonovna , Termiz iqtisodiyot va servis universiteti Tibbiyot fakulteti o'qituvchisi Ilmiy rahbar Rustamov Abdumannop Chori õgʻli , Termiz iqtisodiyot va servis universiteti Tibbiyot fakulteti Davolash ishi talim yoʼnalish 25- 34 guruh talabasi Husan Umbarov Fafzulla o‘g‘li , Termiz iqtisodiyot va servis universiteti Tibbiyot fakulteti Davolash ishi talim yoʼnalish 25- 34 guruh talabasiAbstract
This article discusses the influence of external factors on the embryonic development of the aorta and the main congenital defects of the aorta. The negative effects of maternal infections, harmful habits, medications, environmental factors, and metabolic disorders on fetal aortic formation are analyzed. In addition, the etiology, pathogenesis, clinical manifestations, and diagnostic methods of major congenital anomalies such as aortic coarctation, aortic stenosis, and aortic arch abnormalities are described. The importance of early diagnosis and prevention of congenital cardiovascular defects is emphasized.
Keywords
aorta, embryonic development, external factors, congenital defects, aortic coarctation, aortic stenosis, cardiovascular system, embryogenesis, diagnosis, prevention.
References
Law MA, et al. Coarctation of the Aorta. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430913/
Tikkanen J, Heinonen OP. Risk factors for coarctation of the aorta. Teratology. 1993;47(6):565-572. doi:10.1002/tera.1420470608
Zhang TN, et al. Environmental Risk Factors and Congenital Heart Disease: An Umbrella Review of 165 Systematic Reviews and Meta-Analyses. Front Cardiovasc Med. 2021;8:640729. doi:10.3389/fcvm.2021.640729
Familiari A, et al. Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis. Circulation. 2017;135(8):772-785.
Lynch TA, Abel DE. Teratogens and Congenital Heart Disease. Journal of Diagnostic Medical Sonography. 2015;31(5):301-313.
Centers for Disease Control and Prevention (CDC). Coarctation of the Aorta. Available from: https://www.cdc.gov/heart-defects/about/coarctation-of-the-aorta.htm
Greene CL, et al. Origins of Aortic Coarctation: A Vascular Smooth Muscle Cell Perspective. PMC, 2025.
Yokoyama U, et al. Pathology and molecular mechanisms of coarctation of the aorta. Pediatrics International. 2017.
Ceuppens AS, et al. Aorta pathology and pregnancy-related risks in adult congenital heart disease. PMC, 2023.
do Amaral Lopes SAV, et al. Risk factors for critical and complex congenital heart defects. Seminars in Fetal and Neonatal Medicine. 2023.
Article Statistics
Downloads
Copyright License

This work is licensed under a Creative Commons Attribution 4.0 International License.