Biological sex is not only an important factor in the development of Parkinson's disease (PD), but also determines some of its clinical features. The purpose of the study was to determine the features of the clinical picture of the disease and social factors in patients with PD, as well as their impact on various domains of quality of life, depending on gender. The study included 103 patients with BP (48 men (46.6%), 55 women (53.4%); average age 65.47 ± 9.02 years). The female gender was associated with more severe gait disorder and more pronounced postural disorders. In addition, women had more frequent nausea and vomiting (21.8 vs. 6.3%), frequent urination (72.7 vs. 45.8%), anxiety (47.3 vs. 16.7%) and difficulty falling asleep (45.5 vs. 18.8%). The level of quality of life was statistically significantly lower in women (91.0 [63.5; 112.0] versus 65.0 [44.3; 86.8] points; p < 0.001). So, female Gender was characterized by more pronounced impairments in mobility, daytime activity, emotional well-being, stigmatization, and communication. The analysis of social factors showed that among patients with PD, there are statistically significantly more unmarried (20.0 vs. 4.2%) and widows (29.1 vs. 6.3%). Correlation analysis showed that the main motor and non-motor manifestations of PD reduce the quality of life in men more than in women.  It is concluded that social factors play a greater role in reducing the quality of life in women than clinical ones. The results of the study indicate that women with PD are more vulnerable to a decrease in the quality of life and more in need of psychological support to combat a serious progressive illness

Parkinson's disease, quality of life, gender, non-motor symptoms.

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