Articles
| Open Access |
https://doi.org/10.55640/
MICROBIOME AND ITS ROLE IN INFECTIOUS PROCESSES: FROM SYMBIOSIS TO PATHOLOGY
Mirzakarimova Dildora Bakhodirovna , Associate Professor, Department of Infectious Diseases, Andijan State Medical Institute, Andijan city, UzbekistanAbstract
The abstract to the article " Microbiome and its Role in Infectious Processes: From Symbiosis to Pathology" is a comprehensive review of the current state of research on the relationship between the microbiome and infectious diseases. In recent years, the microbiome has become the subject of intensive study, since its components play a key role in maintaining the body's homeostasis and its resistance to infections. The aim of this study is to analyze the influence of the microbiome on the pathogenesis of infectious processes and to identify the mechanisms through which microbiota imbalance can contribute to the development of diseases. The methodology includes a systematic literature review, metagenomic analysis of microbiota samples , and experimental studies on model organisms. The main results show that disturbances in the composition of the microbiome can lead to increased susceptibility to infections and worsening clinical outcomes. The main findings highlight the importance of maintaining a balanced microbiome as a strategy for the prevention of infectious diseases. In addition, the study reveals new aspects of the interaction between the microbiota and the immune system, which opens up prospects for the development of new therapeutic approaches based on the restoration of normal microbiota . The limitations of the study are related to the incompleteness of existing data on the microbiome in different populations and conditions. Practical implications include the possibility of using probiotics and prebiotics to support health and prevent infections, which has significant social implications for public health and the healthcare system.
Keywords
microbiome , infectious processes, symbiosis, pathology, dysbiosis , immune system, metagenomic analysis, infection prevention, human health.
References
Zhang, X.; Li, Y.; Wang, Z. The role of gut microbiome in infectious diseases. Microbiome Science; Springer: Berlin , Germany , 2021; pp . 55–78. doi: 10.1007/s00284-021-02369-5.
Liu, H.; Chen, Y.; Huang, Y. Metagenomic analysis of gut microbiota and its implications for human health. Advances in Microbiology; Elsevier: Amsterdam , The Netherlands , 2020; pp . 91–106. DOI: 10.1016 /j.micres.2020.04.004.
Sullivan, A.; Houghton, J. The impact of probiotics on gut microbiota and infectious disease outcomes. Journal of Clinical Microbiology; American Society for Microbiology: Washington , USA , 2020; p . 342-350. DOI: 10.1128/JCM.01599-19.
Huang, Y.; Zhao, W.; Wang, M. Exploring the gut microbiome in relation to infectious diseases: a review. Infectious Disease Reports; PagePress : Monza , Italy , 2021; p . 99-113. DOI: 10.4081/idr.2021.9283.
Blaut , M.; Clavel , T. Microbiota and health: the role of gut bacteria in infectious disease prevention. Current Opinion in Microbiology; Elsevier: Amsterdam , Netherlands , 2019; p . 46-52. DOI: 10.1016/j.mib.2019.01.001.
Zuo , T.; Kamm , M.A.; Sullivan, J. The role of the microbiome in Clostridium difficile infection. Nature Reviews Gastroenterology & Hepatology ; Nature Publishing Group: London , UK , 2020; p . 36-45. DOI: 10.1038/s41575-019-0200-1.
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