Platelets play an important role in the process of stopping bleeding in case of damage to the vascular wall and tissues, as well as in the process of intravascular thrombosis. During the implementation of primary platelet-vascular hemostasis (TSH), phases of reactions aimed at the formation of a blood clot are distinguished: adhesion, spreading, release reaction, aggregation and retraction. An important indicator in assessing TSH is the nature of changes in platelet aggregation under the influence of various inducers. Aggregation is rapid and irreversible due to the action of thrombin, adrenaline, adenosine diphosphate (ADP) and ristomycin in certain concentrations. The most reliable methods for assessing TSH are to study the rate and degree of decrease in the optical density of platelet plasma with the addition of aggregation inducers. Platelet aggregation under the action of ADP at a concentration (2.5 mmol/l) and ristomycin (10 mg/ml). ADP-induced aggregation makes it possible to identify a risk group for thrombosis, monitor treatment with disaggregants and confirm the presence of thrombasthenia. The use of this concentration of ADP contributes to the development of complete irreversible aggregation and the lag phase is not observed, and ristomycin-induced aggregation allows us to study the effect of the Willebrandt factor. The aim of the study was to study adenosine diphosphate (ADP)-induced platelet aggregation in patients with coronary heart disease (CHD) with anxiety and depression. It was found that the degree and time of platelet aggregation in individuals with coronary heart disease in combination with anxiety and/or depression were less than in patients with coronary heart disease without mood disorders. The aggregation time was significantly lower in the case of using ADP at a concentration of 1.25 and 2.5 microns. The degree of aggregation was significantly lower in the case of an ADP concentration of 1.25 microns. The results obtained do not support the hypothesis of increased thrombosis in patients with coronary heart disease with anxiety and depressive disorders

coronary heart disease, depression, anxiety, platelet aggregation.

Khabibovna, Y. S., Alisherovna, K. M., Totlibayevich, Y. S., & Davranovna, M. K. (2023). PAINLESS CARDIAC ISCHEMIA AND RHEUMATOID ARTHRIT. Journal of new century innovations, 29(1), 98-105.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., & Totlibayevich, Y. S. (2023). Features of heart failure in patients with thyrotoxicosis. Journal of new century innovations, 29(1), 89-97.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Totlibayevich, Y. S., Nizamitdinovich, K. S., & Baxtiyorovich, U. J. (2023). DIAGNOSTIC VALUE OF CYSTATIN C IN PATIENTS WITH HYPERTENSION AND OBESITY. World Bulletin of Public Health, 22, 55-59.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., Tashtemirovna, E. M. M., Abdukadirovna, A. S., & Jasurovna, J. S. (2023). DEPRESSION, ANXIETY AND QUALITY OF LIFE IN PATIENTS WITH ATRIAL FIBRILLATION. Journal of new century innovations, 39(1), 185-189.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., & Baxtiyorovich, U. J. (2023). THE EFFECTIVENESS OF THYROSTATICS IN THE TREATMENT OF. Journal of new century innovations, 29(1), 79-88.

Khabibovna, Y. S., & Alisherovna, K. M. (2024). STRESS TESTING IN PATIENTS WITH CORONARY HEART DISEASE. Journal of new century innovations, 45(3), 28-33.

Khabibovna, Y. S., & Xudoyberdiyevich, G. X. (2024). THE POSSIBILITIES OF COENZYME Q10 AS PART OF THE COMPLEX THERAPY OF PATIENTS WITH CHRONIC HEART FAILURE. Spectrum Journal of Innovation, Reforms and Development, 25, 116-123.

Tashtemirovna, E. M. M., Khabibovna, Y. S., Alisherovna, K. M., & Erkinovna, K. Z. (2023). Angiopathy in Rheumatoid Arthritis. Miasto Przyszłości, 40, 418-425.

Alisherovna, K. M., Khabibovna, Y. S., Nizamitdinovich, K. S., & Bakhtiyorovich, U. J. (2023). CYSTATIN and KIDNEY FUNCTION. Journal of new century innovations, 38(2), 220-225.

Nizamitdinovich, K. S., Khabibovna, Y. S., Alisherovna, K. M., & Tashtemirovna, E. M. M. (2023). Spinal Injury for Rheumatoid Arthritis. Miasto Przyszłości, 40, 426-432.

Khabibovna, Y. S., Alisherovna, K. M., Erkinovna, K. Z., & Djamshedovna, K. D. (2023). Gender Characteristics of the Course of Rheumatoid Arthritis. Miasto Przyszłości, 40, 438-442.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Nizamitdinovich, K. S., & Abdukadirovna, A. S. (2023). ANTITHROMBOTIC THERAPY IN CARDIOLOGICAL PATIENTS. Journal of new century innovations, 39(1), 169-171.

Erkinovna, K. Z., Khabibovna, Y. S., & Abrorovna, V. N. (2023). MONITORING OF QUALITY OF LIFE IN PATIENTS WITH ARTERIAL HYPERTENSION OF OLDER AGE GROUPS. Academia Science Repository, 4(5), 276-285.

Xabibovna, Y. S., & Buriboevich, N. M. (2021, May). SOME FEATURES OF STRUCTURAL AND FUNCTIONAL CHANGES OF THE MYOCARDIAL IN PATIENTS WITH DIABETES MELLITUS WITH DIASTOLIC HEART FAILURE. In E-Conference Globe (pp. 208-211).

Khabibovna, Y. S., & Buriboevich, N. M. (2021). Change Of Structural And Functional Heart Indicators In Patients With Diabetes Mellitus With Diastolic Heart Failure.

Khabibovna, Y. S. (2020). Оценка Признаков Диастолической Дисфункции Правого Желудочка У Больных С Артериальной Гипертонией. Journal of cardiorespiratory research, 1(2), 88-92.

Yarmukhamedova, S. K., Alisherovna, K. M., Tashtemirovna, E. M. M., & Nizamitdinovich, K. S. (2023). The Effectiveness of Trimetazidine in Arrhythmias. Miasto Przyszłości, 33, 215-221.

Ziyadullaev, S. K., Sultonov, I. I., Dushanova, G. A., & Akbarovna, K. S. (2021). The Effectiveness Of Pharmacotherapy For Dmards With Ra Depending On The C3435t Polymorphism Of The Mdr1 Gene. Int. J. of Aquatic Science, 12(3), 2908-2916.

Islomovich, S. I., Alisherovna, K. M., & Djamshedovna, K. D. (2024). FACTORS OF OSTEOPOROSIS IN PATIENTS WITH CORONARY HEART DISEASE IN COMBINATION WITH RHEUMATOID ARTHRITIS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 132-138.

Islomovich, S. I. (2024). FEATURES OF THE COURSE OF PREGNANCY IN RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 77-84.

Alisherovna, K. M., Nizamitdinovich, K. S., & Islomovich, S. I. (2024). THERAPY OF RHEUMATOID ARTHRITIS DURING PREGNANCYTHE. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 172-180.

Ilkhom, S. (2023). CAJAM–VOLUME 1. ISSUE 1. 2023. Central Asian Journal of Advanced Medicine, 1(01), 16-19.

Islomovich, S. I. (2024). GENDER CHARACTERISTICS OF THE CURRENT RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 3-8.

Djamshedovna, K. D., Alisherovna, K. M., & Islomovich, S. I. (2024). ARTERIAL HYPERTENSION IN RHEUMATOID ARTHRITIS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 139-145.

Nizamitdinovich, K. S., Alisherovna, K. M., & Islomovich, S. I. (2024). CLINICAL COURSE OF BRONCHIAL ASTHMA IN PATIENTS WITH THYROID DISEASES. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 181-187.

Alisherovna, K. M., Nizamitdinovich, K. S., & Islomovich, S. I. (2024). FEATURES OF BONE MINERAL DENSITY IN PATIENTS WITH DISEASES OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 162-171.

Alisherovna, K. M., Islomovich, S. I., & Djamshedovna, K. D. (2024). PSYCHOEMOTIONAL STATE AND QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 124-131.

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Kireev, V. V., & Sultonov, I. I. (2021). Genetic Engineered Preparations-An Innovative Approach in the Treatment of Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 4114-4119.

Hamraeva, N. A., Sultonov, I. I., & Hasanov, F. S. (2020). Systemic lupus erythematosus treatment strategy. Journal of Critical Reviews, 7(9), 269-270.

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Sultonov, I. I., Xasanov, F. S., Eshmuratov, S., Uralov, R. S., Shukurova, D., & Ziyadullayev, S. X. Predictors of Systemic Lupus Erythematosus: A Case-control Study. International journal of health sciences, 6(S10), 175-182.