The purpose of the study. An open, randomized, comparative study of the efficacy, safety and evaluation of the effect of paroxetine and hydroxyzine hydrochloride therapy on platelet serotonin levels in patients with coronary heart disease (CHD) with comorbid anxiety and depressive disorders with a predominance of the anxiety component was conducted.

Materials and methods. The study included 40 patients with chronic coronary heart disease with comorbid mixed anxiety and depressive disorders. Diagnosis of anxiety-depressive disorders were established according to ICD-10. The study included patients who scored 18 or more points on the Hamilton anxiety and depression scales. Results. During treatment with both hydroxyzine hydrochloride and paroxetine, a significant decrease in scores on the Hamilton anxiety and depression scales was observed after 4 weeks, and after 8 weeks the decrease reached 50%. Side effects were observed during treatment with both drugs and quickly passed after their withdrawal. Platelet serotonin decreased significantly during paroxetine therapy.

depression, anxiety, coronary heart disease, paroxetine, hydroxyzine hydrochloride.

Ziyadullaev, S. K., Sultonov, I. I., Dushanova, G. A., & Akbarovna, K. S. (2021). The Effectiveness Of Pharmacotherapy For Dmards With Ra Depending On The C3435t Polymorphism Of The Mdr1 Gene. Int. J. of Aquatic Science, 12(3), 2908-2916.

Islomovich, S. I., Alisherovna, K. M., & Djamshedovna, K. D. (2024). FACTORS OF OSTEOPOROSIS IN PATIENTS WITH CORONARY HEART DISEASE IN COMBINATION WITH RHEUMATOID ARTHRITIS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 132-138.

Islomovich, S. I. (2024). FEATURES OF THE COURSE OF PREGNANCY IN RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 77-84.

Alisherovna, K. M., Nizamitdinovich, K. S., & Islomovich, S. I. (2024). THERAPY OF RHEUMATOID ARTHRITIS DURING PREGNANCYTHE. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 172-180.

Ilkhom, S. (2023). CAJAM–VOLUME 1. ISSUE 1. 2023. Central Asian Journal of Advanced Medicine, 1(01), 16-19.

Islomovich, S. I. (2024). GENDER CHARACTERISTICS OF THE CURRENT RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 3-8.

Djamshedovna, K. D., Alisherovna, K. M., & Islomovich, S. I. (2024). ARTERIAL HYPERTENSION IN RHEUMATOID ARTHRITIS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 139-145.

Nizamitdinovich, K. S., Alisherovna, K. M., & Islomovich, S. I. (2024). CLINICAL COURSE OF BRONCHIAL ASTHMA IN PATIENTS WITH THYROID DISEASES. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 181-187.

Alisherovna, K. M., Nizamitdinovich, K. S., & Islomovich, S. I. (2024). FEATURES OF BONE MINERAL DENSITY IN PATIENTS WITH DISEASES OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 162-171.

Alisherovna, K. M., Islomovich, S. I., & Djamshedovna, K. D. (2024). PSYCHOEMOTIONAL STATE AND QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 124-131.

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Sultonov, I. I., Kh, Z. S., Ruzybakieva, M. R., Kireev, V. V., Aripova, T. U., & Suyarov, A. A. (2021). Pharmacogenetic Aspects of Drug Resistance in Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 4147-4150.

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Kireev, V. V., & Sultonov, I. I. (2021). Genetic Engineered Preparations-An Innovative Approach in the Treatment of Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 4114-4119.

Hamraeva, N. A., Sultonov, I. I., & Hasanov, F. S. (2020). Systemic lupus erythematosus treatment strategy. Journal of Critical Reviews, 7(9), 269-270.

Иргашева, У. З., Султонов, И. И., & Тоиров, Д. Р. (2013). Признаки дебюта системной красной волчанки. Академический журнал Западной Сибири, 9(1), 15-15.

Xasanov, F. S., & Sultonov, I. I. (2023). RHEUMATOID ARTHRITIS TREATED WITH DMARDS AND CARDIOVASCULAR DISEASE RISK. Oriental Journal of Medicine and Pharmacology, 3(02), 45-52.

Sultonov, I. I., Xasanov, F. S., Eshmuratov, S., Uralov, R. S., Shukurova, D., & Ziyadullayev, S. X. Predictors of Systemic Lupus Erythematosus: A Case-control Study. International journal of health sciences, 6(S10), 175-182.

Sultonov, I. I., Khamrayev, X. X., & Xasanov, F. SYSTEMIC LUPUS ERYTHEMATOSUS AND CARDIOVASCULAR PATHOLOGY: WHERE WE AT?.

Uzokov, J. B., Khusainova, M. A., Eshmamatova, F. B., & Mamadiyorova, M. M. (2023). Correction of violations rheology of blood in ischemic heart disease. Science and Education, 4(2), 153-159.

Khaydarov, S. N., Khusainova, M. A., Uzokov, J. B., & Makhmudova, K. D. (2023). Heart failure and the risk of hypoglycemia. Science and Education, 4(5), 222-231.

Khusainova, M. A., Gafforov, K. K., Uzokov, J. B., & Tairova, Z. K. (2023). THE CHANGE IN THE QT INTERVAL IS A MARKER OF THE SEVERITY OF LIVER CIRRHOSIS. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 94-101.

Khusainova, M. A., Khaydarov, S. N., Uzokov, J. B., & Shonazarova, N. K. (2023). QUALITY OF LIFE IN PATIENTS WITH CHOLELITHIASIS IN THE LONG-TERM PERIOD AFTER CHOLECYSTECTOMY. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 231-239.

Buribayevich, N. M., & Bakhtiyorovich, U. J. (2024). VENTRICULAR ARRHYTHMIAS IN HEART FAILURE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. International journal of medical sciences, 4(05), 240-248.

Bakhtiyorovich, U. J., & Buribayevich, N. M. (2024). MENTAL DISORDERS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. International journal of medical sciences, 4(05), 232-239.

Bakhtiyorovich, U. J., & Buribayevich, N. M. (2024). PSYCHOSOMATIC RELATIONSHIPS IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(05), 225-231.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., & Baxtiyorovich, U. J. (2023). THE EFFECTIVENESS OF THYROSTATICS IN THE TREATMENT OF. Journal of new century innovations, 29(1), 79-88.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Totlibayevich, Y. S., Nizamitdinovich, K. S., & Baxtiyorovich, U. J. (2023). DIAGNOSTIC VALUE OF CYSTATIN C IN PATIENTS WITH HYPERTENSION AND OBESITY. World Bulletin of Public Health, 22, 55-59.

Baxtiyorovich, U. J., Alisherovna, K. M., & Mamasoliyevna, D. N. (2023). Features of cognitive impairment in patients with chronic kidney disease at predialysis stages. World Bulletin of Public Health, 22, 49-54.

Rustamovich, T. D., Alisherovna, K. M., Baxtiyorovich, U. J., & Abdurakhmonovich, M. M. (2022). Painless Cardiac Ischemia in Women with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 95-98.

Alisherovna, K. M., Khabibovna, Y. S., Nizamitdinovich, K. S., & Bakhtiyorovich, U. J. (2023). CYSTATIN and KIDNEY FUNCTION. Journal of new century innovations, 38(2), 220-225.

Alisherovna, K. M., Akramovna, I. K., Bakhtiyorovich, U. J., Nizamitdinovich, K. S., Jasurovna, J. S., Kairatovna, R. A., & Abdukholikovna, E. S. (2023). Exacerbations of chronic obstructive pulmonary disease and coronary atherosclerosis. Journal of new century innovations, 39(1), 176-178.

Alisherovna, K. M., Rustamovich, T. D., & Baxtiyorovich, U. J. (2022). The Use of Trimetazidine in Patients with Type 2 Diabetes Mellitus Who Have Suffered a Myocardial Infarction. Czech Journal of Multidisciplinary Innovations, 10, 35-41.

Bakhtiyorovich, U. J. (2024). METABOLISM REGULATOR IN PATIENTS WITH CHRONIC HEART FAILURE AND ANEMIA OF CHRONIC DISEASES. Journal of new century innovations, 45(3), 3-12.

Erkinovna, K. Z., Alisherovna, K. M., Bakhtiyorovich, U. J., & Djamshedovna, K. D. (2023). METABOLIC SYNDROME IN RHEUMATOID ARTHRITIS. Journal of new century innovations, 38(2), 203-211.

Alisherovna, K. M., Rustamovich, T. D., Baxtiyorovich, U. J., & Sobirovna, S. M. (2022). Diabetes Mellitus and Hyperglycemia in Patients with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 99-103.

Djamshedovna, K. D., Alisherovna, K. M., Tashtemirovna, E. M. M., & Bakhtiyorovich, U. J. (2023). THE EFFECT OF PHARMACOTHERAPY ON THE QUALITY OF LIFE OF PREGNANT WOMEN WITH ARTERIAL HYPERTENSION. World Bulletin of Public Health, 27, 37-41.

Bakhtiyorovich, U. J. (2024). FEATURES OF THE COGNITIVE STATUS IN WOMEN WITH IRON DEFICIENCY ANEMIA. Spectrum Journal of Innovation, Reforms and Development, 24, 27-32.

Yarmukhamedova, S. K., Normatov, M. B., & Amirova, S. A. (2021). Modification of structural and functional indicators of the heart in diabetes mellitus patients with diastolic heart failure. Journal of Advanced Medical and Dental Sciences Research, 9(5), 1-4.

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Buribayevich, N. M. (2024). DIABETES MELLITUS with ARTERIAL HYPERTENSION. Journal of new century innovations, 45(3), 20-27.

Buribayevich, N. M., & Tatlibayevich, Y. S. (2023). DIABETES MELLITUS IN COMBINATION WITH CORONARY HEART DISEASE. World Bulletin of Public Health, 27, 42-47.

Buribayevich, N. M. (2024). THE PSYCHOEMOTIONAL STATUS OF ELDERLY PATIENTS WITH HYPERTENSION AND DIABETES MELLITUS. Spectrum Journal of Innovation, Reforms and Development, 24, 33-38.

Buribayevich, N. M., & Tatlibayevich, Y. S. (2023). QUALITY OF LIFE OF PATIENTS WITH DIABETES MELLITUS. World Bulletin of Public Health, 27, 48-52.

Tatlibayevich, Y. S., & Buribayevich, N. M. (2023). Study of Clinical and Laboratory Features of Rheumatoid Arthritis. Miasto Przyszłości, 40, 433-437.