The experience of combined therapy (venlafaxine and cognitive behavioral psychotherapy) of post-stroke depression in patients of a rehabilitation hospital is presented. 38 patients with organic depressive disorder of varying severity were examined according to ICD-10. According to the dominant affect, the patients were divided into 4 groups – with a predominance of an anxious component, a dreary-anxious mixed variant, "classic" dreary depression and astheno-depressive syndrome with an unstable underlying affect. Using psychometric The HADS, HARS, CGI-S and CGI-I scales show the effectiveness of combined therapy for all components of post-stroke depression, and an advanced reduction of the anxiety component is noted. Combination therapy has shown the greatest effectiveness in the treatment of anxiety depressions of moderate severity. The good tolerability and safety of venlafaxine was noted. The conclusion is made about the expediency of using venlafaxine in combination with cognitive behavioral psychotherapy in the rehabilitation of neurological patients in the post-stroke period.

cognitive behavioral psychotherapy, post-stroke depression, venlafaxine, rehabilitation of neurological patients.

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