The aim of the study was to evaluate cognitive functions in patients with type 2 diabetes mellitus (DM2) and arterial hypertension (AH) and the effectiveness of Ginkgo biloba extract. Patients and methods. 120 patients with DM2 and 50 with hypertension were examined without complications, who had not suffered a stroke and/or myocardial infarction, without active complaints of memory loss and other cognitive functions. Exclusion criteria: stroke and/or myocardial infarction, clinically significant diseases of the peripheral arteries and main arteries of the head, decompensation of DM2, decreased glomerular filtration rate <60 ml/min, the presence of proliferative retinopathy and other endocrine diseases. The following methods of assessing cognitive functions were used: the short mental status assessment scale, the Montreal Cognitive Function assessment scale, and the hand-eye coordination test (Parts A and B). Results and discussion. In 85% of patients with DM2, cognitive impairment (CD) was revealed: impaired attention, short-term memory, and speed of thinking. Of these, 82.5% had moderate cognitive decline, and 2.5% had dementia. 30% of patients with hypertension were diagnosed with moderate hypertension, 10% with dementia. At the same time, the severity of CN in patients with DM2 was higher than in patients with hypertension. Ingestion of  Egb 240 mg/day for 3 months had a statistically significant positive effect on cognitive functions (improvement of short-term memory, concentration, speed of thinking) and daily activity. Conclusion. The authors believe that CN is the first sign of encephalopathy in DM2. It was also noted that DM2 has a more pronounced effect on cognitive functions than AG. Egb  can be used as an effective drug for the treatment of CN in these diseases.

type 2 diabetes mellitus; diabetic encephalopathy; cognitive impairment; cognitive functions; arterial hypertension; Egb

Alisherovna, K. M., Akramovna, I. K., Bakhtiyorovich, U. J., Nizamitdinovich, K. S., Jasurovna, J. S., Kairatovna, R. A., & Abdukholikovna, E. S. (2023). Exacerbations of chronic obstructive pulmonary disease and coronary atherosclerosis. Journal of new century innovations, 39(1), 176-178.

Alisherovna, K. M., Islomovich, S. I., & Djamshedovna, K. D. (2024). PSYCHOEMOTIONAL STATE AND QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 124-131.

Alisherovna, K. M., Khabibovna, Y. S., Nizamitdinovich, K. S., & Bakhtiyorovich, U. J. (2023). CYSTATIN and KIDNEY FUNCTION. Journal of new century innovations, 38(2), 220-225.

Alisherovna, K. M., Khabibovna, Y. S., Nizamitdinovich, K. S., & Bakhtiyorovich, U. J. (2023). CYSTATIN and KIDNEY FUNCTION. Journal of new century innovations, 38(2), 220-225.

Alisherovna, K. M., Nizamitdinovich, K. S., & Islomovich, S. I. (2024). THERAPY OF RHEUMATOID ARTHRITIS DURING PREGNANCYTHE. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 172-180.

Alisherovna, K. M., Nizamitdinovich, K. S., & Islomovich, S. I. (2024). FEATURES OF BONE MINERAL DENSITY IN PATIENTS WITH DISEASES OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 162-171.

Alisherovna, K. M., Rustamovich, T. D., & Baxtiyorovich, U. J. (2022). The Use of Trimetazidine in Patients with Type 2 Diabetes Mellitus Who Have Suffered a Myocardial Infarction. Czech Journal of Multidisciplinary Innovations, 10, 35-41.

Alisherovna, K. M., Rustamovich, T. D., Baxtiyorovich, U. J., & Sobirovna, S. M. (2022). Diabetes Mellitus and Hyperglycemia in Patients with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 99-103.

Bakhtiyorovich, U. J. (2024). FEATURES OF THE COGNITIVE STATUS IN WOMEN WITH IRON DEFICIENCY ANEMIA. Spectrum Journal of Innovation, Reforms and Development, 24, 27-32.

Bakhtiyorovich, U. J. (2024). METABOLISM REGULATOR IN PATIENTS WITH CHRONIC HEART FAILURE AND ANEMIA OF CHRONIC DISEASES. Journal of new century innovations, 45(3), 3-12.

Bakhtiyorovich, U. J., & Buribayevich, N. M. (2024). MENTAL DISORDERS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. International journal of medical sciences, 4(05), 232-239.

Bakhtiyorovich, U. J., & Buribayevich, N. M. (2024). PSYCHOSOMATIC RELATIONSHIPS IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(05), 225-231.

Baxtiyorovich, U. J., Alisherovna, K. M., & Mamasoliyevna, D. N. (2023). Features of cognitive impairment in patients with chronic kidney disease at predialysis stages. World Bulletin of Public Health, 22, 49-54.

Buribayevich, N. M. (2024). DIABETES MELLITUS with ARTERIAL HYPERTENSION. Journal of new century innovations, 45(3), 20-27.

Buribayevich, N. M. (2024). THE PSYCHOEMOTIONAL STATUS OF ELDERLY PATIENTS WITH HYPERTENSION AND DIABETES MELLITUS. Spectrum Journal of Innovation, Reforms and Development, 24, 33-38.

Buribayevich, N. M., & Bakhtiyorovich, U. J. (2024). VENTRICULAR ARRHYTHMIAS IN HEART FAILURE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. International journal of medical sciences, 4(05), 240-248.

Buribayevich, N. M., & Tatlibayevich, Y. S. (2023). QUALITY OF LIFE OF PATIENTS WITH DIABETES MELLITUS. World Bulletin of Public Health, 27, 48-52.

Djamshedovna, K. D., Alisherovna, K. M., & Islomovich, S. I. (2024). ARTERIAL HYPERTENSION IN RHEUMATOID ARTHRITIS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 139-145.

Erkinovna, K. Z., Alisherovna, K. M., Bakhtiyorovich, U. J., & Djamshedovna, K. D. (2023). METABOLIC SYNDROME IN RHEUMATOID ARTHRITIS. Journal of new century innovations, 38(2), 203-211.

Hamraeva, N. A., Sultonov, I. I., & Hasanov, F. S. (2020). Systemic lupus erythematosus treatment strategy. Journal of Critical Reviews, 7(9), 269-270.

Ilkhom, S. (2023). CAJAM–VOLUME 1. ISSUE 1. 2023. Central Asian Journal of Advanced Medicine, 1(01), 16-19.

Islomovich, S. I. (2024). FEATURES OF THE COURSE OF PREGNANCY IN RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 77-84.

Islomovich, S. I. (2024). GENDER CHARACTERISTICS OF THE CURRENT RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 3-8.

Islomovich, S. I., Alisherovna, K. M., & Djamshedovna, K. D. (2024). FACTORS OF OSTEOPOROSIS IN PATIENTS WITH CORONARY HEART DISEASE IN COMBINATION WITH RHEUMATOID ARTHRITIS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 132-138.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., & Baxtiyorovich, U. J. (2023). THE EFFECTIVENESS OF THYROSTATICS IN THE TREATMENT OF. Journal of new century innovations, 29(1), 79-88.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Totlibayevich, Y. S., Nizamitdinovich, K. S., & Baxtiyorovich, U. J. (2023). DIAGNOSTIC VALUE OF CYSTATIN C IN PATIENTS WITH HYPERTENSION AND OBESITY. World Bulletin of Public Health, 22, 55-59.

Khaydarov, S. N., Khusainova, M. A., Uzokov, J. B., & Makhmudova, K. D. (2023). Heart failure and the risk of hypoglycemia. Science and Education, 4(5), 222-231.

Khusainova, M. A., Gafforov, K. K., Uzokov, J. B., & Tairova, Z. K. (2023). THE CHANGE IN THE QT INTERVAL IS A MARKER OF THE SEVERITY OF LIVER CIRRHOSIS. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 94-101.

Khusainova, M. A., Khaydarov, S. N., Uzokov, J. B., & Karabayeva, G. K. (2023). KIDNEY CONDITION IN PATIENTS WITH CHRONIC HEART FAILURE. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 102-112.

Khusainova, M. A., Khaydarov, S. N., Uzokov, J. B., & Shonazarova, N. K. (2023). QUALITY OF LIFE IN PATIENTS WITH CHOLELITHIASIS IN THE LONG-TERM PERIOD AFTER CHOLECYSTECTOMY. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 231-239.

Kireev, V. V., & Sultonov, I. I. (2021). Genetic Engineered Preparations-An Innovative Approach in the Treatment of Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 4114-4119.

Nizamitdinovich, K. S., Alisherovna, K. M., & Islomovich, S. I. (2024). CLINICAL COURSE OF BRONCHIAL ASTHMA IN PATIENTS WITH THYROID DISEASES. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 181-187.

Rustamovich, T. D., Alisherovna, K. M., Baxtiyorovich, U. J., & Abdurakhmonovich, M. M. (2022). Painless Cardiac Ischemia in Women with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 95-98.

Sultonov, I. I., Kh, Z. S., Ruzybakieva, M. R., Kireev, V. V., Aripova, T. U., & Suyarov, A. A. (2021). Pharmacogenetic Aspects of Drug Resistance in Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 4147-4150.

Sultonov, I. I., Khamrayev, X. X., & Xasanov, F. SYSTEMIC LUPUS ERYTHEMATOSUS AND CARDIOVASCULAR PATHOLOGY: WHERE WE AT?.

Sultonov, I. I., Xasanov, F. S., Eshmuratov, S., Uralov, R. S., Shukurova, D., & Ziyadullayev, S. X. Predictors of Systemic Lupus Erythematosus: A Case-control Study. International journal of health sciences, 6(S10), 175-182.

Tatlibayevich, Y. S., & Buribayevich, N. M. (2023). FEATURES OF THE QUALITY OF LIFE IN PATIENTS WITH PNEUMONIA. World Bulletin of Public Health, 27, 53-57.

Tatlibayevich, Y. S., & Buribayevich, N. M. (2023). Study of Clinical and Laboratory Features of Rheumatoid Arthritis. Miasto Przyszłości, 40, 433-437.

Uzokov, J. B., Khusainova, M. A., Bekmuradova, M. S., & Makhmudova, K. D. (2023). Dynamics of quality of life indicators during personalized rehabilitation of patients with rheumatoid arthritis with arterial hypertension. Science and Education, 4(5), 196-204.

Uzokov, J. B., Khusainova, M. A., Eshmamatova, F. B., & Mamadiyorova, M. M. (2023). Correction of violations rheology of blood in ischemic heart disease. Science and Education, 4(2), 153-159.

Xasanov, F. S., & Sultonov, I. I. (2023). RHEUMATOID ARTHRITIS TREATED WITH DMARDS AND CARDIOVASCULAR DISEASE RISK. Oriental Journal of Medicine and Pharmacology, 3(02), 45-52.

Ziyadullaev, S. K., Sultonov, I. I., Dushanova, G. A., & Akbarovna, K. S. (2021). The Effectiveness Of Pharmacotherapy For Dmards With Ra Depending On The C3435t Polymorphism Of The Mdr1 Gene. Int. J. of Aquatic Science, 12(3), 2908-2916.

Иргашева, У. З., Султонов, И. И., & Тоиров, Д. Р. (2013). Признаки дебюта системной красной волчанки. Академический журнал Западной Сибири, 9(1), 15-15.

Тоиров, А. Э., Султонов, И. И., & Тоиров, Э. С. (2020). ЗНАЧЕНИЕ ДИСФУНКЦИИ ПОЧЕК У БОЛЬНЫХ ОСТРЫМ ИНФАРКТОМ МИОКАРДА НА ФОНЕ САХАРНОГО ДИАБЕТА 2-ГО ТИПА. Вестник науки и образования, (9-3 (87)), 86-91.

Хамраева, Н. А., Султонов, И. И., & Хасанов, Ф. Ш. У. (2019). Кожные проявления у больных системной красной волчанкой. Вопросы науки и образования, (28 (77)), 128-131.