The purpose of this study is to determine the optimal method for the formation of purulent-inflammatory processes in animals in laboratory conditions in rats.

Given the many different ways of forming purulent wounds in rats, we have selected with the most accurate results. Today, there are many options for modeling purulent wound wounds, but in experimental practice, several basic methods are used. One of them is pre-existing methods (“modeling purulent wounds in rats.” D.Yu. Kharitonov, A.Yu. Kovalenko. Scientific and practical journal, 2017, pp. 57-60.) after the authors compared several methods (the overturned lacquer technique, A.I.Modified technique of Sychennikov, technique of the Belarusian State Medical University, technique of subcutaneous injection of a certain suspension of microbes).

Purulent wound modeling is done in the cranial sac of the rat, since this anatomical sac is protected not only from external influences from the animal itself, but also from it, for example, additional wound contamination microflora in sheet material.  In the cranial sacs of rats, purulent wound modeling with a disposable scalpel, skin and subcutaneous tissue is cut in the longitudinal direction of the body, at a depth of up to 2 parallel incision muscle fascia up to 2.0 CM in length, dropping an interval of 1.0 cm from each other. As a result, a kind of “bridge” is formed. In addition, it is more convenient for visual examination of a purulent wound in the cranial sac of a squid and is also practical in terms of further therapy.

experience, rats, purulent wounds.

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