Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition characterized by persistent respiratory symptoms and airflow limitations, often exacerbated by comorbidities like renal dysfunction and obesity. The coexistence of obesity and renal dysfunction in patients with COPD complicates disease management, requiring multifaceted treatment approaches that address each condition's unique challenges. This article explores the pathophysiology linking COPD, obesity, and renal dysfunction, emphasizing the impact of these comorbidities on disease progression and quality of life. We discuss current treatment approaches, examine novel therapeutic options, and highlight lifestyle modifications that can mitigate symptoms and improve outcomes for patients with this challenging triad.

Chronic Obstructive Pulmonary Disease (COPD), Renal dysfunction, Obesity, Systemic inflammation, Hypoxemia, Comorbidity management.

Barnes, P.J. (2018). Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. Journal of Allergy and Clinical Immunology, 138(1), 16-27. doi: 10.1016/j.jaci.2018.05.019

Thomashow, B.M., et al. (2019). Endothelial microvascular dysfunction and kidney disease in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 200(7), 855-862. doi:10.1164/rccm.201902-0394OC

Incalzi, R.A., et al. (2020). The relationship between COPD severity and renal function: Implications for clinical practice. European Respiratory Journal, 55(3), 1901720. doi:10.1183/13993003.01720-2019

Shah, A.J., et al. (2020). Hypoxemia-induced kidney dysfunction in COPD patients with concurrent obstructive sleep apnea. Chest, 158(5), 1956-1964. Doi: 10.1016/j.chest.2020.04.053

Verma, M., et al. (2020). The obesity paradox in chronic obstructive pulmonary disease: Does it stand in the face of comorbidities? Respiratory Medicine, 167, 105971. doi: 10.1016/j.rmed.2020.105971

Fisher, J.R., et al. (2019). Corticosteroid use in obese COPD patients: Implications for diabetes and electrolyte management. Clinical Respiratory Journal, 13(6), 361-369. doi:10.1111/crj.13046