Ischemic heart disease is one of the main causes of death all over the world. Clinically, causing myocardial infarction is fatal in adults mainly due to atherosclerotic changes in the coronary arteries and sudden vascular spasm caused by stress in young people, in many cases for failure to provide timely treatment measures. Research conducted by the most recent epidemiological taxing professors Khan M, Hashim M, Mustafa H on global disease from 2010 to 2020 shows that cardiac ischemic diseases affect about 126 million people worldwide (1,655 per 100,000 people), accounting for 1.72% of the world's population by country and region, causing 34.4 million and 17.4 million deaths respectively. Males are more likely to be observed compared to females at present at 1,655 per 100,000 population, increasing from 1,845 by 2030. Among the countries of Eastern Europe, the highest incidence is maintained.

coronary artery disease, acute coronary syndrome, Willebrand factor, hemostasis, anticoagulants.

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