Immunohistochemistry methods are of great importance in morphology, namely in forensic histology. Nineteen cases of stangulation mechanical asphyxia in the age group from 28 to 48 years were examined. For comparison, three cases of mechanical asphyxia due to drowning in the age group from 35 to 50 years were studied. The control group consisted of 11 cases of acute ischemic heart disease, six cases of death from traumatic shock. In the course of the study, fibrinogen can be assessed as a substance of early response to injury and a marker of intravital strangulation mechanical asphyxia. This algorithm can be proposed for the diagnosis of strangulation asphyxia.

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