The problem of nausea and vomiting after surgery has accompanied the development of anesthesiology since the very inception of the specialty in the mid- 19th century after the discovery of ether for anesthesia (Moroz V.V., 2004, 2006). However, for a long time these symptoms were not given due attention, considering them a natural and insignificant side effect of anesthesia. In the group of neurosurgical patients, the particular danger of postoperative nausea and vomiting (PONV) is associated with an increase in intracranial and arterial pressure, as well as cerebral blood flow, which is associated with the risk of postoperative hematoma and cerebral edema, and therefore life-threatening dislocations and wedging of the brain ( Tseitlin A.M., 2003; Lee K ., 2012; Matta D . F ., 2011). Emetogenic reactions are the most common reasons for patient dissatisfaction after anesthesia.

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