Relevance of the topic. The search for and study of pharmacological agents for the treatment of patients with migraine is one of the priority problems of modern medicine, since migraine is one of the most widespread and socially significant diseases. In developed countries of Europe and America, migraine affects 3 to 16% of the population, and according to some data, up to 30%. Migraine affects 18% of women, 6% of men, and 4% of children (Stewart W.F. et al., 1994; Rasmussen B.K., 1994; Vein A.M. et al., 1995; Silberstein S.D. et al., 1998; Yakhno H.H. et al., 2001; Amelin A.V. et al., 2001; Chernyak Z.V. et al., 2003). It has been shown that people of working age - 35-40 years old - suffer from migraine more often. Research in recent years has revealed a tendency towards an increase in the number of migraine patients (Stewart W.F. et al., 1994; Amelin A.V. et al., 2001; Yakhno N.N. et al., 2001; Yakhno N.N., Shtulman D.R., 2003).

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