Autoantibodies that are not related to the organ, such as antinuclear antibodies (ANA) and smooth muscle antibodies (SMA), are highly prevalent in patients with autoimmune hepatitis. The liver and kidney microsomal antibody type 1 (LKM1) is a serological marker of type 2 autoimmune hepatitis (AIH-2). Antibodies against liver cell cytosol, namely type 1 antibodies (LC1), are present alongside or separately from anti-LKM1, both indicating the clinical condition of AIH-2. Antibodies against the soluble liver antigen (anti-SLA) are found in type 3 AIH when anti-LC1, ANA, SMA, and anti-LKM1 are negative. However, subsequent studies have shown that this marker can also appear together with other specific antibodies for different types of AIH.

autoimmune hepatitis, autoimmune hepatitis liver cirrhosis, LKM-1/LC1, sp100, gp210, AMA-M2.

Bastian Engel, Alena Laschtowitz, Maciej K. Janik et al. Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review. European Journal of Medical Genetics 2021; 64:e104214

Christen, U., Hintermann, E., 2018. Autoantibodies in autoimmune hepatitis: can epitopes tell us about the etiology of the disease? Front. Immunol. 9 (FEB), 1–10. https://doi.org/10.3389/fimmu.2018.00163

Moy L., Levine J. Autoimmune hepatitis: a classic autoimmune liver disease, Curr. Probl. Pediatr. Adolesc. Health Care 44 (2014) 341–346

Smyk, D.S., 2013. Risk factors for autoimmune hepatitis: from genesand pregnancy to vaccinations and pollutants. Immuno Gastroenterol. https://doi.org/10.7178/ig.32.

Stephens, C., Castiella, A., Gomez-Moreno, E.M., et al., 2016a. Autoantibody presentation in drug-induced liver injury and idiopathic autoimmune hepatitis: the influence of human leucocyte antigen alleles. Pharmacogenetics Genom. 26 (9), 414–422. https://doi.org/10.1097/FPC.0000000000000230

Tairova G.B. Autoimmun gepatitning davolash prinsiplarini takomillashtirish. Amaliy va tibbiyot ilmiy jurnali. 2023;11(02): 443-445

Tairova, G. B., Kurbonova Z. Ch. "Improvement Of Laboratory Diagnosis Of Autoimmune Hepatitis." Galaxy International Interdisciplinary Research Journal 10.12 (2022): 1667–1671.

Tairova G.B. Improving The Principles of Treatment Of Autoimmune Hepatitis. Eurasian Medical Research Periodical. 2023;26:p110-112

Taubert R., Hardtke-Wolenski M., Noyan F., Wilms A. et al. Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies, J. Hepatol. 61 (2014) 1106–1114

Ulff-Møller, C.J., Svendsen, A.J., Viemose, L.N., Jacobsen, S., 2018. Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort. Semin. Arthritis Rheum. https://doi.org/10.1016/j.semarthrit.2017.06.007.