Articles | Open Access | https://doi.org/10.55640/

STUDY OF BIOCHEMICAL MARKERS OF CARBOHYDRATE AND LIPID METABOLISM IN MALE AND FEMALE LABORATORY ANIMALS MODELING METABOLIC SYNDROME AND BONE DESTRUCTION

Anvar Akhmadovich Mavlonov1, Jurayeva Gulrux Bafoyevna2 , 1.Bukhara State Medical Institute, Associate Professor of the Department of Clinical Pharmacology. 2. Bukhara State Medical Institute, assistant kafedra Oftalmology

Abstract

In the experiment, changes in laboratory and biochemical indicators in blood were studied in male and female rabbits modeled with metabolic syndrome and osteoporosis, and the effect of metformin+zinc+omega3 complex was evaluated. Metformin+zinc+omega3 drug can be recommended in practice as a means of pathogenetic treatment of metabolic syndrome and bone destructive changes.

Keywords

metabolic syndrome, osteoporosis, metformin+zinc+omega3 complex.

References

Alessi M. C., Juhan–Vague I. PAI–1 and the metabolic syndrome: the links, causes and consequences. Arterioscler Thromb Vasc Biol 2006; 26 (10): 2200–7.

Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C. Defining the metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues in Definition. . 2004;

Schmerbach K., Patzak A. Metabolic syndrome: 2014; 210 :702–704. doi: 10.1111/apha.12230.

I. Watt , M. Doherty Plain Radiographic Features of Osteoarthritis KD Brandt , M. Doherty , LS Lohmander (Eds.) , Osteoarthritis , Oxford University Press , New York ( 2003 ) , LC Rovati Radiographic Evaluation. 7 (1999), 427-429)

M.A. D'Anjou, M. Moreau, E. Troncy, J. Martel. Pelletier, F. Abram, JP Raynauld et al. Osteophytosis, subchondral bone sclerosis, joint effusion and soft tissue in canine experimental stifling osteoarthritis tissue thickening: a comparison

between 1.5 T magnetic resonance imaging and computer radiography. Vet Surg, 37 (2008), 116-177).

Van Ginneken B, ter Haar Romeny BM, Viergever MA. Computer-aided diagnosis in chest radiography: a survey. IEEE Trans Med Imaging (2001) 20:1228–41. doi: 10.1109/42.974918 ).

Мавлонов А.А. Бобоева Р.Р Метаболик синдром ва остеопороз моделлаштирилган тажриба ҳайвонларида метформин+цинк+омега3 комплексини суяк деструкциясига таъсирини МСКТ ёрдамида бахолаш International Multidisciplinary Research in Academic Science (IMRAS). 2024 September 98-109

Kovaleva M.A., Makarova M.N., Selezneva A.I., Makarov V.G. Primenenie zhivotnyh so spontannoj gipertenziej dlja modelirovanija metabolicheskogo sindroma. Obzory po klinicheskoj farmakologii i lekarstvennoj terapii, 2012; 4: 91–94

Neuhofer A., Wernly B., Leitner L., Sarabi A., Sommer N.G., Staffler G., Zeyda M., Stulnig T.M. An accelerated mouse model for atherosclerosis and adipose tissue inflammation. Cardiovasc Diabetol. 2014 Jan 17;13:23. DOI: 10.1186/1475-2840-13-23

Yunuskhodjaev.A., Mavlonov.A., Saidov.S., Boboeva.R..Estimation of Bone Tissue Changes in Experimental Animals with Metabolic Syndrome under Using MSCT American Journal of Medicine and Medical Sciences 2024, 14(6): 1475-1482

Mavlonov.A., Saidov.S., Mirsultanov.J., Boboeva.R.Features of bone destruction in rabbits with experimental metabolic syndrome The Scientific Temper. (2024) Vol. 15 (1): 1941-1948

Wong SK, Chin KY, Suhaimi FH, Fairus A, Ima-Nirwana S. Animal models of metabolic syndrome: a review. Nutrition & metabolism. 2016; 13:65

Звягина М.В., Маль Г.С., Бушуева О.Ю., Быканова М.А., Летова И.М., Грибовская И.А., Солодилова М.А., Полоников А.В. Влияние генотипов белка-переносчика эфиров холестерина на эффективность гиполипидемической терапии розувастатином у больных ишемической болезнью сердца с атерогенными гиперлипидемиями // Фундаментальные исследования. – 2015. – № 1-3. – С. 517-521

Nomura A., Won H.H., Khera A.V. et al. (2017) Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ. Res., 121(1): 81–88

Shiomi M., Koike T., Ito T. Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins. Atherosclerosis. 2013, vol. 231. no. 1. P.39-47

Roberts D.C.K., West C.E., Redgrave T.G., Smith J.B. Plasma cholesterol concentration in normal and cholesterol-fed rabbits. Atherosclerosis. 1974. vol. 19. no. 3. P. 369-380

Tall A.R. Plasma cholesteryl ester transfer protein. J. Lipid Res. 1993. vol. 34. no. 8. P. 1255-1274

Апрятин С.А., Мжельская К.В.,Трусов Н.В., Балакина А.С., Кулакова С.Н., Сото С.Х., Макаренко М.А.,Ригер Н.А., Тутельян В.А. Сравнительная характеристика in vivo моделей гиперлипидемии у крыс линии Вистар и мышей линии C57Bl/6. Вопр. питания. 2016. № 6. С. 14-23

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STUDY OF BIOCHEMICAL MARKERS OF CARBOHYDRATE AND LIPID METABOLISM IN MALE AND FEMALE LABORATORY ANIMALS MODELING METABOLIC SYNDROME AND BONE DESTRUCTION. (2024). International Journal of Medical Sciences, 4(12), 268-279. https://doi.org/10.55640/