Heavy chain diseases are malignant neoplasms (paraproteinemic hemoblastoses) characterized by hypersecretion of heavy chain fragments and the complete absence of light chain immunoglobulins of various classes, which leads to damage to the lymphatic and hematopoietic systems. Diseases of the γ (gamma), α (alpha), µ (mu) and exceptionally rare – δ (delta) heavy chains are distinguished.

paraproteinemic hemoblastosis, cytostatics, enlarged liver, spleen, lymph nodes, diarrhea, edema, exhaustion.

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